Călina Ion, Demeter Maria, Scărișoreanu Anca, Abbas Awn, Raza Muhammad Asim
National Institute for Laser, Plasma and Radiation Physics, 409 Atomiștilor, 077125 Măgurele, Romania.
Department of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
Gels. 2025 Jan 8;11(1):47. doi: 10.3390/gels11010047.
Hydrogels are widely utilized in industrial and scientific applications owing to their ability to immobilize active molecules, cells, and nanoparticles. This capability has led to their growing use in various biomedical fields, including cell culture and transplantation, drug delivery, and tissue engineering. Among the available synthesis techniques, ionizing-radiation-induced fabrication stands out as an environmentally friendly method for hydrogel preparation. In alignment with the current requirements for cleaner technologies, developing hydrogels using gamma and electron beam irradiation technologies represents a promising and innovative approach for their biomedical applications. A key advantage of these methods is their ability to synthesize homogeneous three-dimensional networks in a single step, without the need for chemical initiators or catalysts. Additionally, the fabrication process is controllable by adjusting the radiation dose and dose rate.
水凝胶因其能够固定活性分子、细胞和纳米颗粒的能力而被广泛应用于工业和科学领域。这种能力使其在各种生物医学领域的应用越来越广泛，包括细胞培养与移植、药物递送和组织工程。在现有的合成技术中，电离辐射诱导制备作为一种环境友好的水凝胶制备方法脱颖而出。符合当前对清洁技术的要求，利用伽马射线和电子束辐照技术开发水凝胶是其生物医学应用的一种有前景且创新的方法。这些方法的一个关键优势是能够一步合成均匀的三维网络，无需化学引发剂或催化剂。此外，通过调整辐射剂量和剂量率可以控制制备过程。
