Pires Bruno, Catarro Gonçalo, Soares Sofia, Gonçalves Joana, Rosado Tiago, Barroso Mário, Araujo André R T S, Gallardo Eugenia
Centro de Investigação em Ciências da Saúde (CICS-UBI), Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal.
Laboratório de Fármaco-Toxicologia, UBIMedical, Universidade da Beira Interior, Estrada Municipal 506, 6200-284 Covilhã, Portugal.
Toxics. 2024 Dec 30;13(1):25. doi: 10.3390/toxics13010025.
Volumetric absorptive microsampling (VAMS) is an emerging technique in clinical and forensic toxicology. It is recognized as a promising alternative to traditional sampling methods, offering an accurate and minimally invasive means of collecting small volumes of biological samples, such as blood, urine, and saliva. Unlike conventional methods, VAMS provides advantages in terms of sample stability, storage, and transportation, as it enables samples to be collected outside laboratory environments without requiring refrigeration. This review explores several VAMS methodologies, with a particular focus on its application for the quantification of drugs and other substances in clinical and forensic toxicology. It compares VAMS to other microsampling techniques, such as dried blood spots (DBSs), highlighting VAMS's superiority in addressing issues related to sample volume consistency and environmental impact. Despite its advantages, VAMS also presents certain limitations, including higher costs and difficulties in detecting underfilled samples. Overall, VAMS stands out as a microsampling technique with the potential to enhance patient compliance and operational efficiency, positioning itself as a viable tool for toxicological analysis in both clinical and forensic contexts.
容积吸收性微量采样（VAMS）是临床和法医毒理学领域中一种新兴的技术。它被认为是传统采样方法的一种有前景的替代方法，提供了一种准确且微创的方式来采集少量生物样本，如血液、尿液和唾液。与传统方法不同，VAMS在样本稳定性、储存和运输方面具有优势，因为它能够在实验室环境外采集样本，而无需冷藏。本文综述探讨了几种VAMS方法，特别关注其在临床和法医毒理学中药物和其他物质定量分析的应用。它将VAMS与其他微量采样技术，如干血斑（DBS）进行比较，突出了VAMS在解决与样本体积一致性和环境影响相关问题方面的优越性。尽管VAMS具有优势，但它也存在某些局限性，包括成本较高以及检测未装满样本存在困难。总体而言，VAMS作为一种微量采样技术脱颖而出，具有提高患者依从性和操作效率的潜力，使其成为临床和法医环境中毒理学分析的可行工具。
