Galal Sara Ahmed, El-Barbary Rasha Aly, Madkour Doaa Karam Abd El Wahed
Dermatology and Venereology Department, Faculty of Medicine (Girls), Al-Azhar University, 53, New Cairo, 3rd Zone Fifth, Settlement, Cairo, Egypt.
Medicine and General Surgery, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Arch Dermatol Res. 2025 Jan 24;317(1):307. doi: 10.1007/s00403-025-03799-7.
Several treatment modalities have been used for the treatment of keloid scarring but the optimal treatment has not yet been identified. Corticosteroids reduce excessive scarring by reducing collagen synthesis. Vitamin D can curb inflammation by inhibiting the activation and migration of leukocytes. Pentoxifylline is a methyl xanthine derivative initially developed for its vasodilatory properties. Evaluation and comparison between three modalities of treatment for keloid; intralesional vitamin D, pentoxifylline, and steroid. Forty-five patients with keloid lesions were divided into 3 groups; The first group: 15 patients were treated with intralesional triamcinolone acetonide. The second group: 15 patients treated with intralesional pentoxifylline. The third group: 15 patients treated with intralesional vitamin D. The response was evaluated clinically, Vancouver scar scale and patient satisfaction scale. At the end of the study, all groups showed highly statistically significant improvement compared to the baseline. The first group which was treated with triamcinolone acetonide showed excellent and good improvement 53% and 47% respectively. The second group which was treated with pentoxifylline showed excellent and good improvement 6.7% and 73.3% respectively. The third group which was treated with vitamin D showed excellent and good 6.7% and 86.7% respectively. Intralesional vitamin D and pentoxifylline are safe and effective therapeutic options for keloid lesions.
几种治疗方式已被用于治疗瘢痕疙瘩，但尚未确定最佳治疗方法。皮质类固醇通过减少胶原蛋白合成来减少过度瘢痕形成。维生素D可通过抑制白细胞的激活和迁移来抑制炎症。己酮可可碱是一种甲基黄嘌呤衍生物，最初因其血管舒张特性而开发。对瘢痕疙瘩的三种治疗方式进行评估和比较；病灶内注射维生素D、己酮可可碱和类固醇。45例瘢痕疙瘩患者分为3组；第一组：15例患者接受病灶内注射曲安奈德治疗。第二组：15例患者接受病灶内注射己酮可可碱治疗。第三组：15例患者接受病灶内注射维生素D治疗。通过临床评估、温哥华瘢痕量表和患者满意度量表来评估反应。在研究结束时，与基线相比，所有组均显示出高度统计学意义的改善。接受曲安奈德治疗的第一组分别有53%和47%的患者显示出优异和良好的改善。接受己酮可可碱治疗的第二组分别有6.7%和73.3%的患者显示出优异和良好的改善。接受维生素D治疗的第三组分别有6.7%和86.7%的患者显示出优异和良好的改善。病灶内注射维生素D和己酮可可碱是治疗瘢痕疙瘩病变的安全有效的治疗选择。
