Ramundi Valentina, Zdouc Mitja M, Donati Enrica, van der Hooft Justin J J, Cimini Sara, Righetti Laura
Laboratory of Organic Chemistry, Wageningen University & Research, 6708 WE, Wageningen, the Netherlands.
Institute for Biological Systems (ISB), National Research Council of Italy (CNR), Via Salaria Km 29.300, Monterotondo Scalo, 00015, Rome, Italy.
Metabolomics. 2025 Jan 24;21(1):19. doi: 10.1007/s11306-024-02210-2.
Rumex sanguineus, a traditional medicinal plant of the Polygonaceae family, is gaining popularity as an edible resource. However, despite its historical and nutritional significance, its chemical composition remains poorly understood. To deepen the understanding of the of Rumex sanguineus composition, an in-depth analysis using non-targeted, mass spectrometry-based metabolomics was performed. METHODS: Rumex roots, stems and leaves samples were analyzed by UHPLC-HRMS and subsequently subjected to feature-based molecular networking.
Overall, 347 primary and specialized metabolites grouped into 8 biochemical classes were annotated. Most of these metabolites (60%) belong to the polyphenols and anthraquinones classes. To investigate potential' toxicity due to the presence of anthraquinones, the amount of emodin was quantified with analytical standard, revealing higher accumulation in leaves compared to stems and roots. This highlights the need for thorough metabolomic studies to understand both beneficial and harmful compounds, especially in plants with historical medicinal use transitioning to modern culinary use.
血见愁酸模（Rumex sanguineus）是蓼科的一种传统药用植物，正作为一种可食用资源而日益受到欢迎。然而，尽管其具有历史和营养意义，但其化学成分仍知之甚少。为了深入了解血见愁酸模的成分，采用基于非靶向质谱的代谢组学进行了深入分析。方法：通过超高效液相色谱-高分辨质谱（UHPLC-HRMS）对酸模的根、茎和叶样本进行分析，随后进行基于特征的分子网络分析。结果与结论：总体而言，共注释了347种初级和特殊代谢物，分为8个生化类别。这些代谢物中的大多数（60%）属于多酚类和蒽醌类。为了研究由于蒽醌的存在而可能产生的毒性，用分析标准品对大黄素的含量进行了定量，结果显示其在叶中的积累量高于茎和根。这突出了进行全面代谢组学研究以了解有益和有害化合物的必要性，特别是对于从传统药用向现代烹饪用途转变的植物。
