Martin M L, Lucid E J, Walker R W
Ann Emerg Med. 1985 Apr;14(4):354-8. doi: 10.1016/s0196-0644(85)80104-9.
We present the case of a 35-year-old man who developed symptoms of the neuroleptic malignant syndrome (NMS) after taking prescribed, moderately high, therapeutic doses of haloperidol. When brought to the emergency department, he was comatose, hypotensive, and had rigid muscle tone and a core body temperature of 42.2 C. Although initial treatment was supportive, intubation, ventilator support, and further care in the intensive care unit were necessary. Ensuing disseminated intravascular coagulation was treated successfully and the patient was weaned from the ventilator on the third day after admission. He was discharged from the hospital 11 days after admission. Recently recognized drug therapy for NMS, such as bromocriptine mesylate and dantrolene sodium, was not used in this case.
我们报告一例35岁男性病例，该患者在服用规定的中等偏高治疗剂量的氟哌啶醇后出现了抗精神病药恶性综合征（NMS）的症状。被送至急诊科时，他处于昏迷状态，血压过低，肌肉强直，核心体温为42.2摄氏度。尽管初始治疗为支持性治疗，但仍有必要进行插管、呼吸机支持以及在重症监护病房进一步护理。随后成功治疗了弥散性血管内凝血，患者在入院后第三天脱离呼吸机。他于入院11天后出院。本病例未使用最近认可的NMS药物疗法，如甲磺酸溴隐亭和丹曲林钠。
