Loewenthal Julia V, Burton Wren, Kamali Shaida, Ramani Subha, Wayne Peter M, Orkaby Ariela R, Aronson Louise
Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Osher Center for Integrative Health, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
J Frailty Aging. 2025 Feb;14(1):100005. doi: 10.1016/j.tjfa.2024.100005. Epub 2025 Jan 1.
Pre-frailty is highly prevalent and multimodal lifestyle interventions are effective for preventing transition to frailty. However, little is known about the potential for medical group visits (MGV) to prevent frailty progression.
To assess the feasibility and acceptability of the MGV Age Self Care-Resilience.
Single-arm mixed methods pilot clinical trial.
Virtual MGV delivered in an ambulatory setting at a U.S. academic medical center.
Community-dwelling older adults (n = 11; age 65+) with pre- to mild frailty.
Age Self Care-Resilience, an 8-week virtual MGV (90-minute sessions once per week) with sessions focused on physical activity, nutrition, social engagement, mind-body practice, and home environment modification.
Primary outcomes were feasibility of recruitment, attendance, satisfaction, and feasibility of study measurements, collected via quantitative and qualitative approaches. Exploratory outcomes included frailty, psychosocial health, and physical function.
A priori feasibility criteria were met for recruitment, with 15 (48 %) of those screened (31) meeting eligibility criteria, 11 (35 %) enrolling (mean age 74.5 yrs), and recruitment completed in less than one month. The nine participants who completed the study attended a mean of 7.2 of 8 sessions and completed 100 % of baseline and follow-up study measures; participants completed 58 % of the home practice log. Themes from participant interviews included: (1) mixed reactions to the recruitment term "pre-frailty;" (2) finding group participation as meaningful and empowering; and (3) perception that the program positively changed attitudes and lifestyle behaviors.
Age Self Care-Resilience is feasible and acceptable to pre- to mildly frail older adults. Next steps include evaluating the efficacy of Age Self Care-Resilience for preventing frailty progression with a fully powered randomized controlled trial.
衰弱前期非常普遍，多模式生活方式干预对预防向衰弱转变有效。然而，关于医疗团队会诊（MGV）预防衰弱进展的潜力知之甚少。
评估MGV年龄自我护理-复原力项目的可行性和可接受性。
单臂混合方法试点临床试验。
在美国一家学术医疗中心的门诊环境中进行的虚拟MGV。
社区居住的衰弱前期至轻度衰弱的老年人（n = 11；年龄65岁及以上）。
年龄自我护理-复原力，一个为期8周的虚拟MGV（每周一次，每次90分钟），课程重点关注身体活动、营养、社交参与、身心练习和家庭环境改造。
主要结果是通过定量和定性方法收集的招募、出勤、满意度以及研究测量的可行性。探索性结果包括衰弱、心理社会健康和身体功能。
招募达到了预先设定的可行性标准，在筛选的31人中，有15人（48%）符合资格标准，11人（35%）入组（平均年龄74.5岁），招募在不到一个月的时间内完成。完成研究的9名参与者平均参加了8次课程中的7.2次，完成了100%的基线和随访研究测量；参与者完成了家庭练习日志的58%。参与者访谈的主题包括：（1）对招募术语“衰弱前期”的不同反应；（2）发现小组参与有意义且能增强能力；（3）认为该项目积极改变了态度和生活方式行为。
年龄自我护理-复原力对衰弱前期至轻度衰弱的老年人是可行且可接受的。下一步包括通过一项充分有力的随机对照试验评估年龄自我护理-复原力预防衰弱进展的疗效。
