Aguilar-Duran H, Fernández M, González-García M, Rincón-Alvarez E, Alberti M, Caro F, Tavera E, Vásquez E, Cortez N, Salinas M, Florenzano M, Florestano C, Buendia-Roldan Ivette
Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, seccion XVI, Tlalpan CP 14080, Mexico City, Mexico.
Hospital de Rehabilitación Respiratoria María Ferrer, Buenos Aires, Argentina.
BMC Pulm Med. 2025 Jan 24;25(1):36. doi: 10.1186/s12890-025-03506-2.
Idiopathic pulmonary fibrosis (IPF) is the most common Interstitial Lung Disease (ILD). It is characterized by dyspnoea and a progressive decline in lung function, which negatively affects life. This study aimed to evaluate Health-Related Quality of Life (HRQoL) in IPF patients in Latin American countries.
Six countries (Argentina, Bolivia, Colombia, Chile, Mexico, and the Dominican Republic) enrolled patients with IPF. They answered the Saint George's Respiratory Questionnaire for Idiopathic Pulmonary Fibrosis (SGRQ-I) and the Hospital Anxiety and Depression Scale (HADS). Demographic characteristics, the Torvan index, and a lung function test were also assessed. IPF was diagnosed according to the ATS/ERS/JRS/ALAT 2018 criteria.
We enlisted 75 patients diagnosed with IPF; 81% were male, with an average age of 74 ± 7. The total SGRQ-I score was 49 ± 23, with a higher score in the activity domain of 70 ± 23. Torvan index average was 17 ± 6. We found that 28% presented anxiety and 35% depression. Besides, we observed that patients requiring oxygen had a worse quality of life (total SGRQ-I 62 ± 22 vs. 45 ± 22, p = 0.003) without finding differences in antifibrotic therapy. We did not find differences in HRQoL when dividing groups according to their altitude above sea level, except for a higher frequency of anxiety in patients living at sea level.
We found similar data compared to those reported in real-life European populations. We also found that anxiety and depression are prevalent. However, they are often underdiagnosed and, therefore, left untreated.
特发性肺纤维化（IPF）是最常见的间质性肺疾病（ILD）。其特征为呼吸困难和肺功能进行性下降，对生活产生负面影响。本研究旨在评估拉丁美洲国家IPF患者的健康相关生活质量（HRQoL）。
六个国家（阿根廷、玻利维亚、哥伦比亚、智利、墨西哥和多米尼加共和国）招募了IPF患者。他们回答了特发性肺纤维化圣乔治呼吸问卷（SGRQ-I）和医院焦虑抑郁量表（HADS）。还评估了人口统计学特征、Torvan指数和肺功能测试。IPF根据2018年ATS/ERS/JRS/ALAT标准进行诊断。
我们招募了75例诊断为IPF的患者；81%为男性，平均年龄为74±7岁。SGRQ-I总分49±23，活动领域得分更高，为70±23。Torvan指数平均为17±6。我们发现28%的患者存在焦虑，35%的患者存在抑郁。此外，我们观察到需要吸氧的患者生活质量较差（SGRQ-I总分62±22 vs. 45±22，p = 0.003），抗纤维化治疗方面未发现差异。按海拔高度分组时，我们未发现HRQoL存在差异，但海平面居住患者焦虑发生率较高。
我们发现的数据与欧洲现实人群报告的数据相似。我们还发现焦虑和抑郁很普遍。然而，它们往往诊断不足，因此未得到治疗。
