Mikami T, Higashihara T, Yasuda M, Kunihiro K, Kodama H, Izawa H, Okada I
Avian Dis. 1985 Jan-Mar;29(1):250-5.
Quail embryo fibroblasts were used to investigate how rabbit and chicken antisera against chicken erythrocytes carrying different B alleles of the major histocompatibility antigens affect the neutralization of herpesvirus of turkeys (HVT). Although the neutralizing activities of these antisera were rather low, the HVT propagated in chicken embryo fibroblasts (CEF) from certain genotypic embryos was neutralized more by the antisera to the corresponding erythrocytes. After absorption of these antisera with homologous erythrocytes, the neutralizing activity of the absorbed sera was reduced slightly. These results reveal that the virion antigens of HVT might be partially associated with the host cell antigens of the fibroblast infected with the virus. The virus grown in these cells might incorporate the host cell antigens, including histocompatibility antigens, into the virion envelope.
鹌鹑胚胎成纤维细胞被用于研究针对携带主要组织相容性抗原不同B等位基因的鸡红细胞的兔抗血清和鸡抗血清如何影响火鸡疱疹病毒（HVT）的中和作用。尽管这些抗血清的中和活性相当低，但来自某些基因型胚胎的鸡胚成纤维细胞（CEF）中增殖的HVT被针对相应红细胞的抗血清中和得更多。用同源红细胞吸收这些抗血清后，吸收后血清的中和活性略有降低。这些结果表明，HVT的病毒粒子抗原可能部分与感染该病毒的成纤维细胞的宿主细胞抗原相关。在这些细胞中生长的病毒可能将包括组织相容性抗原在内的宿主细胞抗原整合到病毒粒子包膜中。
