Levshakova Aleksandra, Kaneva Maria, Ninayan Ruzanna, Borisov Evgenii, Satymov Evgenii, Shmalko Alexander, Logunov Lev, Kuchmizhak Aleksandr, Kulchin Yuri N, Manshina Alina, Khairullina Evgeniia
Institute of Chemistry, St. Petersburg State University, 199034 St. Petersburg, Russia.
Center for Optical and Laser Materials Research, St. Petersburg University, 199034 St. Petersburg, Russia.
Materials (Basel). 2025 Jan 17;18(2):425. doi: 10.3390/ma18020425.
Deep eutectic solvents (DES) have emerged as versatile, sustainable media for the synthesis of nanomaterials due to their low toxicity, tunability, and biocompatibility. This study develops a one-step method to modify commercially available screen-printed electrodes (SPE) using laser-induced pyrolysis of DES, consisting of choline chloride and tartaric acid with dissolved nickel acetate and dispersed graphene. The electrodes were patterned using a 532 nm continuous-wave laser for the in situ formation of Ni nanoparticles decorated on graphene sheets directly on the SPE surface (Ni-G/SPE). The synthesis parameters, specifically laser power and graphene concentration, were optimized using the Nelder-Mead method to produce modified Ni-G/SPEs with maximized electrochemical response to dopamine. Electrochemical characterization of the developed sensor by differential pulse voltammetry revealed its broad linear detection range from 0.25 to 100 μM and high sensitivity with a low detection limit of 0.095 μM. These results highlight the potential of laser-assisted DES synthesis to advance electrochemical sensing technologies, particularly for the detection of biogenic amines.
由于其低毒性、可调节性和生物相容性，深共熔溶剂（DES）已成为用于合成纳米材料的通用、可持续的介质。本研究开发了一种一步法，通过激光诱导DES热解来修饰市售的丝网印刷电极（SPE），该DES由氯化胆碱和酒石酸与溶解的醋酸镍和分散的石墨烯组成。使用532 nm连续波激光对电极进行图案化处理，以在SPE表面直接原位形成装饰在石墨烯片上的镍纳米颗粒（Ni-G/SPE）。使用Nelder-Mead方法优化合成参数，特别是激光功率和石墨烯浓度，以制备对多巴胺具有最大电化学响应的修饰Ni-G/SPE。通过差分脉冲伏安法对所开发传感器进行的电化学表征显示，其线性检测范围从0.25到100 μM，具有高灵敏度，检测限低至0.095 μM。这些结果突出了激光辅助DES合成在推进电化学传感技术方面的潜力，特别是用于生物胺的检测。
