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海洋来源的多糖及其在创伤愈合应用中的治疗潜力 - 综述。

Marine-derived polysaccharides and their therapeutic potential in wound healing application - A review.

机构信息

Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University (MRSPTU), Bathinda 151001, Punjab, India.

Department of Pharmaceutical Technology, Faculty of Pharmacy, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.

出版信息

Int J Biol Macromol. 2023 Dec 31;253(Pt 6):127331. doi: 10.1016/j.ijbiomac.2023.127331. Epub 2023 Oct 10.

Abstract

Polysaccharides originating from marine sources have been studied as potential material for use in wound dressings because of their desirable characteristics of biocompatibility, biodegradability, and low toxicity. Marine-derived polysaccharides used as wound dressing, provide several benefits such as promoting wound healing by providing a moist environment that facilitates cell migration and proliferation. They can also act as a barrier against external contaminants and provide a protective layer to prevent further damage to the wound. Research studies have shown that marine-derived polysaccharides can be used to develop different types of wound dressings such as hydrogels, films, and fibres. These dressings can be personalised to meet specific requirements based on the type and severity of the wound. For instance, hydrogels can be used for deep wounds to provide a moist environment, while films can be used for superficial wounds to provide a protective barrier. Additionally, these polysaccharides can be modified to improve their properties, such as enhancing their mechanical strength or increasing their ability to release bioactive molecules that can promote wound healing. Overall, marine-derived polysaccharides show great promise for developing effective and safe wound dressings for various wound types.

摘要

海洋来源的多糖因其具有良好的生物相容性、可生物降解性和低毒性等特点,已被研究作为潜在的伤口敷料材料。用作伤口敷料的海洋来源多糖通过提供促进细胞迁移和增殖的湿润环境,具有促进伤口愈合等多种益处。它们还可以作为阻挡外部污染物的屏障,并提供保护层,防止伤口进一步受损。研究表明,海洋来源的多糖可用于开发不同类型的伤口敷料,如水凝胶、薄膜和纤维。这些敷料可以根据伤口的类型和严重程度进行个性化定制,以满足特定的需求。例如,水凝胶可用于深部伤口,以提供湿润的环境,而薄膜可用于浅部伤口,以提供保护性屏障。此外,这些多糖可以进行修饰以改善其性能,例如增强其机械强度或增加其释放生物活性分子的能力,这些分子可以促进伤口愈合。总的来说,海洋来源的多糖在开发各种类型伤口的有效和安全伤口敷料方面具有很大的应用前景。

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