Alwhaibi Monira
Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11149, Saudi Arabia.
Medication Safety Research Chair, College of Pharmacy, King Saud University, Riyadh 11149, Saudi Arabia.
J Clin Med. 2025 Jan 9;14(2):370. doi: 10.3390/jcm14020370.
Mental health issues can significantly affect the health-related quality of life (HRQoL) of adults suffering from hyperlipidemia. Therefore, in this study, the aim was to examine how depression and anxiety are related to the HRQoL of adults with hyperlipidemia. Data from the Medical Expenditure Panel Survey for 2016 through 2022 were used to identify adult patients diagnosed with hyperlipidemia aged 18 or older. The RAND-12 Physical and Mental Component Summary (PCS and MCS) was used to determine HRQoL. After considering variables such as age, gender, socioeconomic status, and comorbidities, linear regression was used to investigate the relationship between anxiety, depression, and HRQoL in individuals with hyperlipidemia. A sample of 7984 adults with hyperlipidemia was identified; 9.0% experienced depression, 10.2% had anxiety, and 6.8% had both disorders. The HRQoL mean scores were lowest for adults with depression and anxiety compared to those with hyperlipidemia only. Results from the adjusted linear regression analysis revealed that hyperlipidemia patients with depression (MCS: β = -5.535, -value < 0.0001), anxiety (MCS: β = -4.406, -value < 0.0001), and both depression and anxiety (MCS: β = -8.730, -value < 0.0001) had a significantly lower HRQoL compared to patients with hyperlipidemia only. However, in this study, it was also found that those who were physically active and employed had notably higher scores on the PCS and MCS than those who were not. The links between anxiety, depression, and lower HRQoL in patients with hyperlipidemia are clarified in this nationally representative study. This research also revealed the adverse effects of coexisting chronic conditions on HRQoL while emphasizing the benefits of employment and regular exercise. Importantly, these findings provide a compelling case for enhancing healthcare planning, allocating resources, and promoting lifestyle changes in adults with hyperlipidemia, underlining the importance of addressing mental health issues in this population.
心理健康问题会显著影响高脂血症成年人的健康相关生活质量（HRQoL）。因此，在本研究中，目的是探讨抑郁和焦虑与高脂血症成年人的HRQoL之间的关系。使用2016年至2022年医疗支出面板调查的数据来确定18岁及以上被诊断为高脂血症的成年患者。采用兰德12项身心健康综合量表（PCS和MCS）来测定HRQoL。在考虑年龄、性别、社会经济地位和合并症等变量后，使用线性回归研究高脂血症患者中焦虑、抑郁与HRQoL之间的关系。确定了7984名高脂血症成年患者样本；9.0%经历过抑郁，10.2%有焦虑，6.8%同时患有这两种疾病。与仅患有高脂血症的成年人相比，患有抑郁和焦虑的成年人的HRQoL平均得分最低。调整后的线性回归分析结果显示，患有抑郁（MCS：β = -5.535，P值<0.0001）、焦虑（MCS：β = -4.406，P值<0.0001）以及同时患有抑郁和焦虑（MCS：β = -8.730，P值<0.0001）的高脂血症患者的HRQoL明显低于仅患有高脂血症的患者。然而，在本研究中还发现，积极锻炼且有工作的人在PCS和MCS上的得分明显高于没有这些情况的人。在这项具有全国代表性的研究中，明确了高脂血症患者中焦虑、抑郁与较低HRQoL之间的联系。这项研究还揭示了并存慢性病对HRQoL的不利影响，同时强调了就业和定期锻炼的益处。重要的是，这些发现为加强医疗保健规划、资源分配以及促进高脂血症成年人的生活方式改变提供了有力依据，突显了在这一人群中解决心理健康问题的重要性。
