Toumasis Panagiotis, Vrioni Georgia, Gardeli Ioanna, Michelaki Aikaterini, Exindari Maria, Orfanidou Maria
Postgraduate Master Program "Ocular Surgery", School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
J Clin Med. 2025 Jan 11;14(2):430. doi: 10.3390/jcm14020430.
: is an important phytopathogenic fungus affecting over 500 plant species worldwide. However, this fungus rarely causes disease in humans. : We reported the first case of endophthalmitis due to , describing microbiological diagnostic approaches. Also, we performed a systematic review of human infections by this plant pathogen in literature. We searched PubMed, Scopus, and Web of Science databases from inception to 31 December 2024. : Our case involved a male patient who presented with photophobia and pain in his right eye. His recent medical history revealed a superficial corneal injury caused by a metal burr three months prior, managed unsuccessfully by topical treatment and subsequent conjunctival flap surgery two months later. Ophthalmological and microbiological investigations, including microscopic examination, cultures, and DNA sequencing of ocular specimens, revealed endophthalmitis. Despite intravenous and intravitreal antifungal therapy, the patient's condition continued to worsen, eventually leading to enucleation. Regarding the literature review, we identified 12 additional cases of human infections previously reported in literature. Overall, was primarily associated with ocular infections (76.9% of cases), followed by skin infections and combined skin-joint infections. The majority of patients with infection (63.6%) had no known immunosuppressive factors. Clinical outcomes were unfavorable in 46.15% of cases. : is an emerging cause of human infections, even in immunocompetent hosts, with a predilection for ocular infections. Further research is warranted to elucidate the pathogenesis of fungal infections caused by plant pathogens in humans.
是一种重要的植物致病真菌，在全球范围内影响超过500种植物。然而，这种真菌很少引起人类疾病。我们报告了首例由引起的眼内炎病例，并描述了微生物学诊断方法。此外，我们对该植物病原体引起的人类感染进行了文献系统综述。我们检索了从数据库建立到2024年12月31日的PubMed、Scopus和Web of Science数据库。我们的病例涉及一名男性患者，他出现畏光和右眼疼痛。他最近的病史显示，三个月前因金属毛刺导致浅表角膜损伤，经局部治疗未成功，两个月后进行了结膜瓣手术。眼科和微生物学检查，包括眼部标本的显微镜检查、培养和DNA测序，显示为眼内炎。尽管进行了静脉和玻璃体内抗真菌治疗，患者的病情仍继续恶化，最终导致眼球摘除。关于文献综述，我们在文献中另外发现了12例人类感染病例。总体而言，主要与眼部感染相关（占病例的76.9%），其次是皮肤感染和皮肤-关节联合感染。大多数感染患者（63.6%）没有已知的免疫抑制因素。46.15%的病例临床结果不佳。是人类感染的一个新兴原因，即使在免疫功能正常的宿主中也是如此，且倾向于引起眼部感染。有必要进行进一步研究以阐明植物病原体在人类中引起真菌感染的发病机制。
