Korinek A M, Languille M, Bonnet F, Thibonnier M, Sasano P, Lienhart A, Viars P
Br J Anaesth. 1985 Apr;57(4):407-11. doi: 10.1093/bja/57.4.407.
The effect of extradural morphine on antidiuretic hormone (ADH) secretion was assessed for the first 6 h after surgery in three groups of patients. Surgery was conducted under extradural bupivacaine: thereafter patients in group I (n = 6) received further injections of bupivacaine, patients in group II (n = 6) received an extradural injection of morphine and in patients in group III (n = 5) both bupivacaine and morphine, were administered extradurally. In group I, plasma ADH values remained unchanged throughout the study. In contrast, in the two groups of patients receiving extradural morphine a delayed and stepwise increase in plasma ADH concentration was documented. These results indicate that extradural morphine induces ADH secretion and suggest that this effect is the consequence of the migration of morphine to the brainstem.
在三组患者中评估了硬膜外吗啡对术后最初6小时抗利尿激素（ADH）分泌的影响。手术在硬膜外布比卡因麻醉下进行：此后，第一组（n = 6）患者接受布比卡因的进一步注射，第二组（n = 6）患者接受硬膜外注射吗啡，第三组（n = 5）患者同时接受硬膜外布比卡因和吗啡。在第一组中，整个研究过程中血浆ADH值保持不变。相比之下，在接受硬膜外吗啡的两组患者中，记录到血浆ADH浓度延迟且逐步升高。这些结果表明硬膜外吗啡可诱导ADH分泌，并提示这种作用是吗啡向脑干迁移的结果。
