盐酸西托维林对乙状结肠收缩运动的影响：一项针对肠易激综合征的双盲、安慰剂对照交叉研究。
The effect of secoverine hydrochloride on stimulated sigmoid motility: a double-blind, placebo controlled cross-over study in irritable bowel syndrome.
作者信息
Ehsanullah M, Lee D A, Williams T, Pollard P, Gazzard B
出版信息
Br J Clin Pharmacol. 1985 Mar;19(3):301-5. doi: 10.1111/j.1365-2125.1985.tb02647.x.
Abstract
The effect of oral secoverine hydrochloride on neostigmine-stimulated sigmoid motility in 12 patients with irritable bowel syndrome was studied in a double-blind placebo-controlled cross-over study. Both spontaneous and stimulated motor activity were significantly reduced by the compound in comparison with placebo. The most sensitive indices were the frequency of wave activity, maximum amplitude and motility index. Two patients reported mild dizziness after secoverine.
摘要
在一项双盲、安慰剂对照的交叉研究中，研究了口服盐酸西托溴铵对12例肠易激综合征患者新斯的明刺激的乙状结肠运动的影响。与安慰剂相比，该化合物显著降低了自发和刺激的运动活性。最敏感的指标是波活动频率、最大振幅和运动指数。两名患者在服用西托溴铵后报告有轻度头晕。
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