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1
The effect of secoverine hydrochloride on stimulated sigmoid motility: a double-blind, placebo controlled cross-over study in irritable bowel syndrome.盐酸西托维林对乙状结肠收缩运动的影响：一项针对肠易激综合征的双盲、安慰剂对照交叉研究。
Br J Clin Pharmacol. 1985 Mar;19(3):301-5. doi: 10.1111/j.1365-2125.1985.tb02647.x.
2
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Int J Clin Pharmacol Ther Toxicol. 1989 Jan;27(1):47-50.
3
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Eur J Clin Pharmacol. 1988;33(6):571-5. doi: 10.1007/BF00542489.
4
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An endoscopic method to study the relationship between bowel habit and motility of the ascending and sigmoid colon.一种用于研究排便习惯与升结肠和乙状结肠运动之间关系的内镜检查方法。
Gastrointest Endosc. 1986 Jun;32(3):185-9. doi: 10.1016/s0016-5107(86)71801-4.
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9
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10
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引用本文的文献

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Bulking agents, antispasmodics and antidepressants for the treatment of irritable bowel syndrome.用于治疗肠易激综合征的容积性泻剂、抗痉挛药和抗抑郁药。
Cochrane Database Syst Rev. 2011 Aug 10;2011(8):CD003460. doi: 10.1002/14651858.CD003460.pub3.
2
Effect of secoverine on colonic myoelectric activity in diverticular disease of the colon.
Dig Dis Sci. 1987 Aug;32(8):833-40. doi: 10.1007/BF01296705.
3
Reduction by cimetropium bromide of the colonic motor response to eating in patients with the irritable bowel syndrome.溴化西托溴铵对肠易激综合征患者进食后结肠运动反应的抑制作用
Eur J Clin Pharmacol. 1988;33(6):571-5. doi: 10.1007/BF00542489.

本文引用的文献

1
MOTILITY OF THE PELVIC COLON. IV. ABDOMINAL PAIN ASSOCIATED WITH COLONIC HYPERMOTILITY AFTER MEALS.盆腔结肠的蠕动。IV. 餐后结肠运动亢进相关的腹痛
Gut. 1965 Apr;6(2):105-12. doi: 10.1136/gut.6.2.105.
2
Human colonic motility: a comparative study of normal subjects, patients with ulcerative colitis, and patients with the irritable colon syndrome. II. The effect of prostigmin.人类结肠运动：正常受试者、溃疡性结肠炎患者和肠易激综合征患者的比较研究。II. 新斯的明的作用。
Gastroenterology. 1961 Jan;40:18-26.
3
Human colonic motility: a comparative study of normal subjects, patients with ulcerative colitis, and patients with the irritable colon syndrome. I. Resting patterns of motility.人类结肠运动：正常受试者、溃疡性结肠炎患者及肠易激综合征患者的比较研究。I. 静息运动模式。
Gastroenterology. 1961 Jan;40:1-17.
4
Secoverine selectively antagonizes muscarinic effects in various in vivo preparations.塞库维林能在多种体内制剂中选择性拮抗毒蕈碱样效应。
Eur J Pharmacol. 1981 Apr 24;71(1):165-8. doi: 10.1016/0014-2999(81)90403-9.
5
Pharmacology of secoverine, a new spasmolytic agent with specific antimuscarinic properties. Part 2: General pharmacological properties.具有特定抗毒蕈碱特性的新型解痉剂西科韦林的药理学。第2部分：一般药理学特性。
Arzneimittelforschung. 1980;30(9):1526-34.
6
Pharmacology of secoverine, a new spasmolytic agent with specific antimuscarinic properties. Part 1: Antimuscarinic and spasmolytic effects.具有特定抗毒蕈碱特性的新型解痉剂西库维林的药理学。第1部分：抗毒蕈碱和解痉作用。
Arzneimittelforschung. 1980;30(9):1517-26.
7
The nervous system of the gut.肠道的神经系统。
Gastroenterology. 1981 Jun;80(6):1571-94.
8
Site of pain from the irritable bowel.肠易激综合征的疼痛部位
Lancet. 1980 Aug 30;2(8192):443-6. doi: 10.1016/s0140-6736(80)91885-1.
9
Observations on the mechanism of abdominal pain.关于腹痛机制的观察
Gut. 1969 Jan;10(1):19-31. doi: 10.1136/gut.10.1.19.
10
Drug usage in the irritable colon syndrome.肠易激综合征中的药物使用
Med J Aust. 1972 May 27;1(22):1126-31.

盐酸西托维林对乙状结肠收缩运动的影响：一项针对肠易激综合征的双盲、安慰剂对照交叉研究。

The effect of secoverine hydrochloride on stimulated sigmoid motility: a double-blind, placebo controlled cross-over study in irritable bowel syndrome.

作者信息

Ehsanullah M, Lee D A, Williams T, Pollard P, Gazzard B

出版信息

Br J Clin Pharmacol. 1985 Mar;19(3):301-5. doi: 10.1111/j.1365-2125.1985.tb02647.x.

DOI:10.1111/j.1365-2125.1985.tb02647.x
PMID:3986085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1463735/
Abstract

The effect of oral secoverine hydrochloride on neostigmine-stimulated sigmoid motility in 12 patients with irritable bowel syndrome was studied in a double-blind placebo-controlled cross-over study. Both spontaneous and stimulated motor activity were significantly reduced by the compound in comparison with placebo. The most sensitive indices were the frequency of wave activity, maximum amplitude and motility index. Two patients reported mild dizziness after secoverine.

摘要

在一项双盲、安慰剂对照的交叉研究中，研究了口服盐酸西托溴铵对12例肠易激综合征患者新斯的明刺激的乙状结肠运动的影响。与安慰剂相比，该化合物显著降低了自发和刺激的运动活性。最敏感的指标是波活动频率、最大振幅和运动指数。两名患者在服用西托溴铵后报告有轻度头晕。