Davison J S, Greenwood B, Najafi-Farashah A, Read N W
Br J Pharmacol. 1983 Jun;79(2):525-9. doi: 10.1111/j.1476-5381.1983.tb11027.x.
The isolated perfused stomach of the mouse was used to study the effect of atropine and secoverine on bethanechol-induced gastric acid secretion and gastric motility. Both atropine and secoverine inhibited cholinergically induced gastric acid secretion and gastric motility. Inhibition of gastric acid secretion by atropine and secoverine occurred at a similar dose-range (10(-9) and 2 X 10(-9) M). Secoverine inhibited bethanechol-induced hypermotility at doses (10(-11) M and above) that were lower than those of atropine (2 X 10(-9) M and above) required to produce this effect. Secoverine, unlike atropine markedly inhibited gastric motility at lower doses than those which affected secretion.
采用小鼠离体灌流胃来研究阿托品和塞克维林对氨甲酰甲胆碱诱导的胃酸分泌及胃动力的影响。阿托品和塞克维林均抑制胆碱能诱导的胃酸分泌及胃动力。阿托品和塞克维林对胃酸分泌的抑制作用出现在相似的剂量范围（10⁻⁹和2×10⁻⁹ M）。塞克维林在低于阿托品（2×10⁻⁹ M及以上）产生此效应所需的剂量（10⁻¹¹ M及以上）时，就能抑制氨甲酰甲胆碱诱导的胃动力亢进。与阿托品不同，塞克维林在低于影响分泌的剂量时就能显著抑制胃动力。
