Edmondstone W M, Wilson A G
Br J Dis Chest. 1985 Jan;79(1):27-36. doi: 10.1016/0007-0971(85)90004-x.
The incidence and clinical features of sarcoidosis were studied in a retrospective survey of 156 patients attending two South London hospitals between 1969 and 1982. Sixty-eight patients were Caucasian, 59 were Black West Indian or African immigrants and 29 were immigrants racially derived from Indo-Pakistan (Asians). The annual incidence of sarcoidosis in the local community in 1977-78 was 19.8 per 10(5) for Blacks and 16.8 per 10(5) for Asians compared with 1.5 per 10(5) for Caucasians. Erythema nodosum was a more common presenting feature in Caucasians than in Blacks (P less than 0.001) or Asians (P less than 0.05). Blacks developed sarcoidosis at a later age than Caucasians (P less than 0.05) and were less likely to present as a chance finding on a chest radiograph (P less than 0.05). They had more widespread extrathoracic disease than Caucasians (P less than 0.001) and were more commonly treated with corticosteroids (P less than 0.001). In the Asians there was a male predominance compared with Caucasians (P less than 0.01). Asians also had more extrathoracic sarcoidosis than Caucasians (P less than 0.001) and more of them were treated with corticosteroids (P less than 0.05). A stage 2 chest radiograph at presentation (P less than 0.05) and skin sarcoidosis (P less than 0.05) were less common in Asians than in Blacks, but otherwise there were no significant differences between the two groups. In this study the incidence of sarcoidosis in Asians approached that in Blacks, while the clinical features were intermediate in severity between Blacks and Caucasians. In both Blacks and Asians the disease was more common, more severe and more extensive than in Caucasians.
在一项对1969年至1982年间就诊于伦敦南部两家医院的156例患者的回顾性调查中，研究了结节病的发病率和临床特征。68例患者为白种人，59例为西印度黑人或非洲移民，29例为印度 - 巴基斯坦裔移民（亚洲人）。1977 - 1978年当地社区结节病的年发病率，黑人每10（5）人中有19.8例，亚洲人每10（5）人中有16.8例，而白种人每10（5）人中有1.5例。结节性红斑在白种人中作为首发症状比在黑人（P<0.001）或亚洲人（P<0.05）中更常见。黑人患结节病的年龄比白种人晚（P<0.05），且在胸部X线片上偶然发现的可能性较小（P<0.05）。他们的胸外疾病比白种人更广泛（P<0.001），且更常接受皮质类固醇治疗（P<0.001）。与白种人相比，亚洲人男性占优势（P<0.01）。亚洲人的胸外结节病也比白种人多（P<0.001），且更多人接受皮质类固醇治疗（P<0.05）。就诊时胸部X线片为2期（P<0.05）和皮肤结节病（P<0.05）在亚洲人中比在黑人中少见，但除此之外两组之间无显著差异。在本研究中，亚洲人结节病的发病率接近黑人，而临床特征的严重程度介于黑人和白种人之间。在黑人和亚洲人中，该疾病都比白种人更常见、更严重且更广泛。
