Omidian Hossein, Wilson Renae L, Castejon Ana M
Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Pharmaceuticals (Basel). 2025 Jan 18;18(1):127. doi: 10.3390/ph18010127.
Peptide-loaded poly(lactide-co-glycolide) (PLGA) nanocarriers represent a transformative approach to addressing the challenges of peptide-based therapies. These systems offer solutions to peptide instability, enzymatic degradation, and limited bioavailability by providing controlled release, targeted delivery, and improved stability. The versatility of PLGA nanocarriers extends across therapeutic domains, including cancer therapy, neurodegenerative diseases, vaccine development, and regenerative medicine. Innovations in polymer chemistry, surface functionalization, and advanced manufacturing techniques, such as microfluidics and electrospraying, have further enhanced the efficacy and scalability of these systems. This review highlights the key physicochemical properties, preparation strategies, and proven benefits of peptide-loaded PLGA systems, emphasizing their role in sustained drug release, immune activation, and tissue regeneration. Despite remarkable progress, challenges such as production scalability, cost, and regulatory hurdles remain.
负载肽的聚（丙交酯-共-乙交酯）（PLGA）纳米载体是应对基于肽的疗法所面临挑战的一种变革性方法。这些系统通过提供控释、靶向递送和提高稳定性，为肽的不稳定性、酶降解和有限的生物利用度提供了解决方案。PLGA纳米载体的多功能性延伸到各个治疗领域，包括癌症治疗、神经退行性疾病、疫苗开发和再生医学。聚合物化学、表面功能化以及微流控和电喷雾等先进制造技术的创新进一步提高了这些系统的功效和可扩展性。本综述重点介绍了负载肽的PLGA系统的关键物理化学性质、制备策略和已证实的益处，强调了它们在持续药物释放、免疫激活和组织再生中的作用。尽管取得了显著进展，但生产可扩展性、成本和监管障碍等挑战仍然存在。
