Cotogni Paolo, De Carli Luca
Pain Management and Palliative Care, Department of Anesthesia, Intensive Care and Emergency, Molinette Hospital, University of Turin, 10126 Turin, Italy.
Clinical Nutrition Unit, ASL Città di Torino, 10128 Turin, Italy.
Nutrients. 2025 Jan 13;17(2):271. doi: 10.3390/nu17020271.
The impact of home parenteral nutrition (HPN) on the quality of life (QoL) of cancer patients has been previously investigated. However, scarce data are available regarding near-death QoL in patients with cancer receiving HPN. This study aims to investigate the changes of QoL in these patients in the last two months before death. This is a secondary analysis of a previous, prospective, longitudinal, observational study. QoL was assessed using the EORTC QLQ-C30 questionnaire. Eighty-four adult cancer patients who died on HPN and had filled out the questionnaire between 31 and 60 days (M2) and within 30 days prior (M1) to death were included in this analysis. The questionnaires filled out at M2 and M1 were compared with those filled out by the same patients at HPN start (T0). At M2, there was a significant improvement in both the global QoL and symptoms scales ( < 0.001 and < 0.033, respectively), while at M1, a significant improvement in the global QoL scale persisted ( < 0.035) compared with T0. Our study first reports that HPN, if started early and according to European guidelines, is associated with an improvement in the QoL of patients with cancer even in the last two months before death.
家庭肠外营养（HPN）对癌症患者生活质量（QoL）的影响此前已得到研究。然而，关于接受HPN治疗的癌症患者濒死期生活质量的数据却很匮乏。本研究旨在调查这些患者在死亡前两个月内生活质量的变化。这是一项对先前一项前瞻性、纵向观察性研究的二次分析。使用欧洲癌症研究与治疗组织（EORTC）QLQ-C30问卷对生活质量进行评估。本分析纳入了84例接受HPN治疗并在死亡前31至60天（M2）以及死亡前30天内（M1）填写了问卷的成年癌症患者。将M2和M1时填写的问卷与同一患者在开始接受HPN治疗时（T0）填写的问卷进行比较。在M2时，总体生活质量和症状量表均有显著改善（分别为<0.001和<0.033），而在M1时，与T0相比，总体生活质量量表仍有显著改善（<0.035）。我们的研究首次报告，若早期开始并按照欧洲指南进行HPN治疗，即使在癌症患者死亡前两个月，也与生活质量的改善相关。
