Quinn M A, Pearce P, Fortune D W, Koh S H, Hsieh C, Cauchi M
Br J Obstet Gynaecol. 1985 Apr;92(4):399-406. doi: 10.1111/j.1471-0528.1985.tb01115.x.
The incidence and levels of cytoplasmic steroid receptors were studied in 155 endometrial carcinomas: oestrogen receptors (ER) were measured in all samples, progesterone receptors (PR) in 148 and androgen receptors (AR) in 118. Well-differentiated adenocarcinomas were significantly more likely to contain ER, PR and AR than were poorly-differentiated tumours, and mean values of ER and PR content were significantly higher in well-differentiated adenocarcinomas than in less-differentiated tumours. Receptor profiles in adenosquamous carcinomas and clear-cell carcinomas were similar to those in adenocarcinomas. Deeply invasive tumours were significantly less likely to be ER, PR or AR positive and, even when positive, such tumours had significantly lower mean levels of ER and PR. Poorly-differentiated tumours were significantly more likely to be ER-negative PR-positive than well-differentiated adenocarcinomas and adenosquamous carcinomas.
对155例子宫内膜癌患者的细胞质甾体受体的发生率和水平进行了研究：对所有样本均检测了雌激素受体（ER），148例检测了孕激素受体（PR），118例检测了雄激素受体（AR）。高分化腺癌比低分化肿瘤更有可能含有ER、PR和AR，且高分化腺癌的ER和PR含量平均值显著高于低分化肿瘤。腺鳞癌和透明细胞癌的受体谱与腺癌相似。深度浸润性肿瘤ER、PR或AR阳性的可能性显著降低，即使呈阳性，此类肿瘤的ER和PR平均水平也显著较低。低分化肿瘤ER阴性PR阳性的可能性显著高于高分化腺癌和腺鳞癌。
