Andreev V P
Biull Eksp Biol Med. 1985 Mar;99(3):370-3.
Study of serial semi-thin (0.5 micron) metacrylate and paraffinic (8 microns) of rat kidney sections 6, 12, 24 and 48 h after subcutaneous injection of mercury bichloride at a dose of 0.6 mg/100 g bw has revealed that injury to different parts of the canalicular nephron is of heterogeneous character. The proximal part of the nephron demonstrates both complete and partial necrosis of nephrocyte cytoplasm. The distal parts of the nephron and collecting tubules are characterized by partial necrosis of the apical cytoplasm. Within the period between 12 and 24 h after the mercury bichloride injection, intracellular reparative processes are observed, in addition to destruction, in partially damaged but viable nephrocytes, which is confirmed by the enlargement of the nucleolic size. Regeneration of the tubular epithelium due to cellular restoration was unmarked 24 h after the mercury bichloride injection.
对皮下注射剂量为0.6mg/100g体重的二氯化汞后6、12、24和48小时的大鼠肾脏切片进行连续半薄（0.5微米）甲基丙烯酸酯和石蜡（8微米）切片研究发现，小管状肾单位不同部位的损伤具有异质性。肾单位的近端部分显示肾细胞胞质既有完全坏死也有部分坏死。肾单位的远端部分和集合小管的特征是顶端胞质部分坏死。在注射二氯化汞后的12至24小时内，除了破坏外，在部分受损但仍存活的肾细胞中观察到细胞内修复过程，这通过核仁大小的增大得到证实。注射二氯化汞24小时后，由于细胞修复导致的肾小管上皮再生不明显。
