[Autoradiographic study of DNA synthesis in epithelial cells of albino rat kidney tubules as affected by corrosive sublimate nephrosis].

The analysis of 3H-thymidine radioautographs of semithin (0.5 micron) methacrylate sections of white rat kidney has shown that 72 h after corrosive sublimate injection in a dose of 0.5 mg/100 g bw, pronounced heterogeneity of impulse thymidine mark distribution stipulated by asynchronous DNA replication in damaged nephrocytes was noted. Thymidine mark is to be observed in some heavily damaged nephrocytes, retaining around the nucleus a negligible amount of cytoplasm. Thymidine mark concentration in the peripheral zone of nuclei typical only of nephrocytes with increased cytoplasm amount testifies to the fact that during S-period repairing processes take place in the damaged nephrocytes, leading to normalization of nuclear-cytoplasmic shifts.