Wang Jingjing, Qi Xueting, Wang Guozheng, Wang Weijing, Zhang Dongfeng
Department of Epidemiology and Health Statistics, the School of Public Health of Qingdao University, 308 Ningxia Road, Qingdao, 266071, Shandong, People's Republic of China.
Sci Rep. 2025 Jan 25;15(1):3177. doi: 10.1038/s41598-025-87823-w.
Several modifiable health factors in Life's Essential 8 (LE8) are linked to nutritional anemia and can assess overall cardiovascular health (CVH). This study explored the associations of CVH measured by LE8 score with nutritional anemia and iron deficiency anemia (IDA), including the mediating role of inflammatory biomarkers. This prospective cohort study included 181,069 participants from UK Biobank. CVH was categorized into low (0-49), medium (50-79), and high (80-100) based on the LE8 score. Weibull regression models were used to quantify the association between CVH and nutritional anemia and IDA. During a median follow-up of 8.6 years, 6749 cases of nutritional anemia occurred, including 92% (6223/6749) IDA cases. After adjusting for covariates, participants with moderate CVH and high CVH had a 44% and 54% lower risk of nutritional anemia (Moderate: hazard ratio [HR] 0.56; 95% confidence interval [CI], 0.51-0.60; High: HR 0.46; 95% CI, 0.41-0.51), and a 46% and 54% lower risk of IDA (Moderate: HR 0.54; 95% CI, 0.50-0.59; High: HR 0.46; 95% CI, 0.41-0.51), respectively, compared to those with low CVH. An L-shaped association was observed between CVH score and both types of anemia. Inflammatory biomarkers explained 22.1% and 21.6% of the associations between CVH and nutritional anemia and IDA, respectively. Higher CVH scores were associated with lower risk of nutritional anemia and IDA, and these associations may be partially mediated by inflammatory biomarkers. These findings emphasize the importance of CVH and inflammation in preventing nutritional anemia.
生命必需的八项健康因素（LE8）中的几个可改变的健康因素与营养性贫血相关，并且可以评估整体心血管健康（CVH）。本研究探讨了用LE8评分衡量的CVH与营养性贫血和缺铁性贫血（IDA）之间的关联，包括炎症生物标志物的中介作用。这项前瞻性队列研究纳入了来自英国生物银行的181,069名参与者。根据LE8评分，CVH被分为低（0-49）、中（50-79）和高（80-100）三个等级。采用威布尔回归模型来量化CVH与营养性贫血和IDA之间的关联。在中位随访8.6年期间，发生了6749例营养性贫血病例，其中92%（6223/6749）为IDA病例。在调整协变量后，与低CVH的参与者相比，中度CVH和高度CVH的参与者发生营养性贫血的风险分别降低了44%和54%（中度：风险比[HR]0.56；95%置信区间[CI]，0.51-0.60；高度：HR 0.46；95%CI，0.41-0.51），发生IDA的风险分别降低了46%和54%（中度：HR 0.54；95%CI，0.50-0.59；高度：HR 0.46；95%CI，0.41-0.51）。在CVH评分与两种类型的贫血之间均观察到L形关联。炎症生物标志物分别解释了CVH与营养性贫血和IDA之间关联的22.1%和21.6%。较高的CVH评分与较低的营养性贫血和IDA风险相关，并且这些关联可能部分由炎症生物标志物介导。这些发现强调了CVH和炎症在预防营养性贫血中的重要性。
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