Wimalasekara Ruwani L, White Dawn, Kumar Ayush
Department of Microbiology, University of Manitoba, Winnipeg, MB, Canada.
NPJ Antimicrob Resist. 2025 Jan 25;3(1):4. doi: 10.1038/s44259-024-00074-z.
Regulatory elements controlling gene expression fine-tune bacterial responses to environmental cues, including antimicrobials, to optimize survival. Acinetobacter baumannii, a pathogen notorious for antimicrobial resistance, relies on efficient efflux systems. Though the role of efflux systems in antibiotic expulsion are well recognized, the regulatory mechanisms controlling their expression remain understudied. This review explores the current understanding of these regulators, aiming to inspire strategies to combat bacterial resistance and improve therapeutic outcomes.
控制基因表达的调控元件可微调细菌对包括抗菌药物在内的环境信号的反应，以优化其生存能力。鲍曼不动杆菌是一种因耐药性而臭名昭著的病原体，它依赖于高效的外排系统。尽管外排系统在抗生素排出中的作用已得到充分认识，但其表达的调控机制仍未得到充分研究。本综述探讨了目前对这些调控因子的认识，旨在激发对抗细菌耐药性和改善治疗效果的策略。
