Malshy Kamil, Yuen Kit, Steinmetz Alexis, Osinski Thomas, Rappold Phillip, Rabinowitz Ronald
Department of Urology, University of Rochester Medical Center, Rochester, NY.
Department of Urology, University of Rochester Medical Center, Rochester, NY; Department of Urology, University of California San Diego, San Diego, CA.
Urology. 2025 May;199:191-196. doi: 10.1016/j.urology.2025.01.040. Epub 2025 Jan 27.
This review examines the historical evolution of testicular cancer (TCa) treatment, emphasizing the transformative impact of World War II. Prior to the war, cases of more than 50 testicular tumors were exceedingly rare. The mobilization of American troops, especially after the German Blitz, resulted in widespread military health screenings, leading to a surge in incidental TCa diagnoses during the 1940s. This pivotal moment triggered rapid advancements in TCa pathology classification, surgical techniques, tumor marker utilization, and breakthroughs in radiation and chemotherapy. Military-driven research and practices fundamentally reshaped TCa treatment, significantly improving patient outcomes and setting new standards in this disease.
本综述考察了睾丸癌（TCa）治疗的历史演变，着重强调了第二次世界大战所带来的变革性影响。战前，超过50例睾丸肿瘤的病例极为罕见。美国军队的动员，尤其是在德国闪电战之后，导致了广泛的军事健康检查，使得20世纪40年代偶然诊断出的睾丸癌病例激增。这一关键时刻引发了睾丸癌病理学分类、手术技术、肿瘤标志物利用以及放疗和化疗方面的快速进展。军事驱动的研究与实践从根本上重塑了睾丸癌治疗，显著改善了患者的治疗效果，并为此疾病设定了新的标准。
