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[腹膜后淋巴结清扫术治疗睾丸生殖细胞肿瘤——机器人辅助技术是否优于开放手术方式?]

[Retroperitoneal lymphadenectomy in the treatment of testicular germ cell tumors-Is the robot-assisted technique superior to the open surgical approach?].

作者信息

Angerer Markus, Dieckmann Klaus-Peter, Wülfing Christian

机构信息

Klinik für Urologie, Asklepios Klinik Altona, Paul-Ehrlich-Straße 1, 22673, Hamburg, Deutschland.

Hodentumorzentrum Hamburg-West, Klinik für Urologie, Asklepios Klinik Altona, Hamburg, Deutschland.

出版信息

Urologie. 2025 Sep 15. doi: 10.1007/s00120-025-02678-3.

DOI:10.1007/s00120-025-02678-3
PMID:40952482
Abstract

BACKGROUND

Retroperitoneal lymph node dissection (RPLND) is an established treatment modality for nonseminomatous germ cell tumours (NSGCT) and selected seminomas. The advent of minimally invasive techniques, particularly robot-assisted RPLND (R-RPLND), involves the prospects of reducing procedure-related morbidity while maintaining oncologic efficacy.

MATERIALS AND METHODS

We performed a narrative review comparing contemporary data on R‑RPLND and open RPLND (O-RPLND) across different clinical settings (primary, clinical stages I-II, and postchemotherapy). Guideline recommendations are reviewed regarding results from prospective and retrospective studies, as well as recent meta-analyses.

RESULTS

R‑RPLND consistently demonstrated advantages in perioperative outcomes, including reduced blood loss, shorter length of hospital stay, and faster convalescence. High-grade complication rates (Clavien-Dindo ≥ III) were comparable or lower than with O‑RPLND. Oncologic outcomes, including recurrence-free survival, were noninferior across all stages. In the postchemotherapy setting, R‑RPLND was associated with lower morbidity, though surgical feasibility is highly dependent on tumour size, location, and prior abdominal surgery.

CONCLUSION

R‑RPLND represents a safe and effective alternative to O‑RPLND in selected patients when performed in high-volume centres. Its perioperative advantages, coupled with equivalent short-term oncologic outcomes, render R‑RPLND an attractive option. However, high-quality randomised trials with long-term follow-up are required to confirm oncologic equivalence and to refine patient selection criteria.

摘要

背景

腹膜后淋巴结清扫术(RPLND)是一种既定的非精原细胞性生殖细胞肿瘤(NSGCT)和部分精原细胞瘤的治疗方式。微创技术的出现,尤其是机器人辅助腹膜后淋巴结清扫术(R-RPLND),有望在保持肿瘤学疗效的同时降低手术相关的发病率。

材料与方法

我们进行了一项叙述性综述,比较了不同临床背景(原发性、临床I-II期和化疗后)下R-RPLND和开放性腹膜后淋巴结清扫术(O-RPLND)的当代数据。对前瞻性和回顾性研究结果以及近期的荟萃分析的指南建议进行了综述。

结果

R-RPLND在围手术期结果方面始终显示出优势,包括减少失血、缩短住院时间和更快康复。高级别并发症发生率(Clavien-Dindo≥III级)与O-RPLND相当或更低。包括无复发生存率在内的肿瘤学结果在所有阶段均非劣效。在化疗后背景下,R-RPLND的发病率较低,尽管手术可行性高度依赖于肿瘤大小、位置和既往腹部手术情况。

结论

在高容量中心对选定患者进行R-RPLND时,它是O-RPLND的一种安全有效的替代方法。其围手术期优势,加上等效的短期肿瘤学结果,使R-RPLND成为一个有吸引力的选择。然而,需要高质量的长期随访随机试验来确认肿瘤学等效性并完善患者选择标准。

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本文引用的文献

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Perioperative morbidity of open retroperitoneal lymph node dissection for testicular germ cell tumors: an in-depth single center analysis according to European Association of Urology guidelines of complication reporting and a scoping literature review.睾丸生殖细胞肿瘤开放腹膜后淋巴结清扫术的围手术期发病率:根据欧洲泌尿外科学会并发症报告指南进行的深入单中心分析及文献综述
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Matched-pair analysis of peri-operative and oncological outcomes of robot-assisted vs open retroperitoneal lymph node dissection.机器人辅助与开放腹膜后淋巴结清扫术围手术期及肿瘤学结局的配对分析
BJU Int. 2025 Jul;136(1):150-158. doi: 10.1111/bju.16747. Epub 2025 Apr 22.
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NCCN Guidelines® Insights: Testicular Cancer, Version 2.2025.美国国立综合癌症网络(NCCN)指南见解:睾丸癌,2025年第2版
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Assessing complications from retroperitoneal lymph node dissection for testicular cancer in North America.评估北美地区睾丸癌腹膜后淋巴结清扫术的并发症
Can Urol Assoc J. 2025 Jun;19(6):167-172. doi: 10.5489/cuaj.9042.
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Mobilize the Troops! Military Involvement in the History of Testicular Cancer.动员部队!军事参与睾丸癌的历史。
Urology. 2025 May;199:191-196. doi: 10.1016/j.urology.2025.01.040. Epub 2025 Jan 27.
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Retroperitoneal Lymph Node Dissection in Patients with Stage II Seminomatous Germ Cell Tumour.腹膜后淋巴结清扫术在 II 期精原细胞瘤患者中的应用。
Eur Urol Focus. 2024 May;10(3):361-363. doi: 10.1016/j.euf.2024.06.011. Epub 2024 Aug 1.
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Primary retroperitoneal lymph node dissection for metastatic non-seminomatous germ cell tumours: outcomes and adjuvant chemotherapy.转移性非精原细胞瘤性生殖细胞肿瘤的原发性腹膜后淋巴结清扫术:结果与辅助化疗
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