Nôga Diana A, Meth Elisa M S, Pacheco André P, Cedernaes Jonathan, Xue Pei, Benedict Christian
Department of Pharmaceutical Biosciences, Uppsala University, Box 593, Husargatan 3, Uppsala, 751 24, Sweden.
Department of Research and Innovation, Division of Mental Health and Addiction, Oslo University Hospital, Sognsvannsveien 21, Oslo, 0372, Norway.
BMC Med. 2025 Jan 27;23(1):44. doi: 10.1186/s12916-025-03882-w.
Lifestyle choices, such as dietary patterns and sleep duration, significantly impact the health of the digestive system and may influence the risk of mortality from digestive system cancer.
This study aimed to examine the associations between sleep duration, dietary habits, and mortality from digestive system cancers. The analysis included 406,584 participants from the UK Biobank cohort (54.1% women; age range: 38-73 years), with sleep duration classified as short (≤ 6 h, 24.2%), normal (7-8 h, 68.4%), and long (≥ 9 h, 7.4%). Healthy eating habits were defined as a daily intake of at least 25 g of fibre, seven portions of fruits and vegetables, and fewer than four servings of meat per week. These dietary factors were combined into a score ranging from 0 (least healthy) to 3 (healthiest). Cox proportional hazards regression analyses were conducted, with a median follow-up period of 12.6 years, ending on September 30, 2021.
3949 participants died from cancer of the digestive system. Both short and long sleep duration were associated with an increased risk of mortality from cancer of the digestive system (1.09 (1.01-1.18) and 1.14 (1.03-1.27), respectively). Additionally, a diet score ≥ 1 was linked to a lower cancer risk (0.72-0.91 (0.59-0.96)). Adjusting for smoking, type 2 diabetes, and body mass index (BMI) status eliminated the association between sleep duration and digestive cancer mortality. The association between healthy dietary patterns and the risk of digestive system cancer mortality did not vary by sleep duration.
Aberrant sleep durations may increase the risk of mortality from digestive system cancer, potentially through smoking, higher BMI, and type 2 diabetes. However, aberrant sleep durations do not seem to reduce the protective effects of a healthy dietary pattern.
生活方式的选择，如饮食习惯和睡眠时间，对消化系统健康有显著影响，并可能影响消化系统癌症的死亡风险。
本研究旨在探讨睡眠时间、饮食习惯与消化系统癌症死亡率之间的关联。分析纳入了英国生物银行队列中的406,584名参与者（女性占54.1%；年龄范围：38 - 73岁），睡眠时间分为短睡眠（≤6小时，占24.2%）、正常睡眠（7 - 8小时，占68.4%）和长睡眠（≥9小时，占7.4%）。健康的饮食习惯定义为每天摄入至少25克纤维、七份水果和蔬菜，且每周肉类摄入量少于四份。这些饮食因素被综合为一个从0（最不健康）到3（最健康）的分数。进行了Cox比例风险回归分析，中位随访期为12.6年，截至2021年9月30日。
3949名参与者死于消化系统癌症。短睡眠和长睡眠持续时间均与消化系统癌症死亡风险增加相关（分别为1.09（1.01 - 1.18）和1.
