Marin Raul E, Gardner Dale, Cook Daniel, Armien Anibal G, Fortunato Renée H, Riet-Correa Franklin, Uzal Francisco A
Faculty of Agricultural Sciences, National University of Jujuy, Jujuy, Argentina.
Poisonous Plant Research Laboratory, United States Department of Agriculture, Agricultural Research Service, Logan, UT, USA.
J Vet Diagn Invest. 2025 Mar;37(2):375-379. doi: 10.1177/10406387241311815. Epub 2025 Jan 27.
Spontaneous intoxication by was diagnosed in a flock of 300 sheep in Jujuy province, northwestern Argentina, that grazed an area heavily invaded by this plant. The main clinical signs were intention tremors, ataxia, and progressive loss of condition. Autopsy of 2 affected animals revealed loss of body condition. The main microscopic changes were fine cytoplasmic vacuolation of cells in the cerebrum, cerebellum, thyroid and adrenal glands, kidney, liver, pancreas, urinary bladder, and lymph nodes, and swollen axons in the cerebellum. Ultrastructurally, the cytoplasmic vacuoles consisted of dilated secondary lysosomes. Composite leaf and stem samples of analyzed by high-performance liquid chromatography contained 0.05% swainsonine. The diagnosis of intoxication by was made based on the clinical history and signs; gross, microscopic, and ultrastructural changes; and detection of swainsonine in the plant.
阿根廷西北部胡胡伊省的一群300只绵羊被诊断为因[植物名称未给出]自发中毒，这群羊在一片被这种植物严重入侵的区域放牧。主要临床症状为意向性震颤、共济失调和身体状况逐渐变差。对2只患病动物进行尸检发现身体状况消瘦。主要的微观变化是大脑、小脑、甲状腺、肾上腺、肾脏、肝脏、胰腺、膀胱和淋巴结中的细胞出现细微的细胞质空泡化，以及小脑中的轴突肿胀。在超微结构上，细胞质空泡由扩张的次级溶酶体组成。通过高效液相色谱分析的[植物名称未给出]复合叶和茎样本含有0.05%的苦马豆素。根据临床病史和症状、大体、微观和超微结构变化以及在植物中检测到苦马豆素，做出了[植物名称未给出]中毒的诊断。
