Ribatti Domenico, Tamma Roberto, Annese Tiziana
Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Policlinico, Piazza G. Cesare, 11, 70124, Bari, Italy.
Inflamm Res. 2020 Nov;69(11):1103-1110. doi: 10.1007/s00011-020-01394-2. Epub 2020 Aug 17.
Multiple sclerosis (MS) is an autoimmune disease, characterized by multiple demyelination of axons in both white and gray matter in the Central Nervous System (CNS). There is increasing evidence to support the notion that angiogenesis and chronic inflammation are mutually related. Different immune cells, including monocytes-macrophages, lymphocytes, neutrophils, mast cells (MCs) and dendritic cells are able to secrete an array of angiogenic cytokines, which promote growth, migration, and activation of endothelial cells. MCs play various roles in MS pathogenesis, influencing the innate immune response in peripheral tissues and in CNS. The aim of this review article is to discuss the role of MCs in MS pathogenesis with particular reference to the involvement of these inflammatory cells in the angiogenic processes occurring during MS.
多发性硬化症（MS）是一种自身免疫性疾病，其特征是中枢神经系统（CNS）的白质和灰质中轴突出现多处脱髓鞘。越来越多的证据支持血管生成与慢性炎症相互关联这一观点。包括单核细胞 - 巨噬细胞、淋巴细胞、中性粒细胞、肥大细胞（MCs）和树突状细胞在内的不同免疫细胞能够分泌一系列血管生成细胞因子，这些因子可促进内皮细胞的生长、迁移和激活。MCs在MS发病机制中发挥多种作用，影响外周组织和CNS中的固有免疫反应。这篇综述文章的目的是讨论MCs在MS发病机制中的作用，特别提及这些炎症细胞在MS病程中发生的血管生成过程中的参与情况。
