Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratary of Aging Biology, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Key Laboratory of Molecular Radiation Oncology Hunan Province, Changsha, Hunan, China; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Central South University, Changsha, Hunan, China.
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Int Immunopharmacol. 2021 Jun;95:107558. doi: 10.1016/j.intimp.2021.107558. Epub 2021 Mar 17.
Rosacea is a chronic, relapsing inflammatory skin disease featured by abnormal activation of immune responses, vascular dysfunction and prominent permeability barrier alterations. Aspirin, as the first nonsteroidal anti-inflammatory drug (NSAID), is widely used for various inflammatory conditions due to its anti-inflammatory and anti-angiogenic properties. However, its effects on rosacea are unclear. In this study, we demonstrated that aspirin dramatically improved pathological phenotypes in LL37-induced rosacea-like mice. The RNA-sequencing analysis revealed that aspirin alleviated rosacea-like skin dermatitis mainly via modulating immune responses. Mechanically, we showed that aspirin decreased the production of chemokines and cytokines associated with rosacea, and suppressed the Th1- and Th17-polarized immune responses in LL37-induced rosacea-like mice. Besides, aspirin administration decreased the microvessels density and the VEGF expression in rosacea-like skin. We further demonstrated that aspirin inhibited the activation of NF-κB signaling and the release of its downstream pro-inflammatory cytokines. Collectively we showed that aspirin exerts a curative effect on rosacea by attenuating skin inflammation and angiogenesis, suggesting a promising therapeutic candidate for the treatment of rosacea.
酒渣鼻是一种慢性、复发性炎症性皮肤病，其特征为免疫应答异常激活、血管功能障碍和明显的渗透性屏障改变。阿司匹林作为第一种非甾体抗炎药（NSAID），因其具有抗炎和抗血管生成特性，被广泛用于各种炎症性疾病。然而，其对酒渣鼻的作用尚不清楚。在本研究中，我们证明了阿司匹林可显著改善 LL37 诱导的酒渣鼻样小鼠的病理性表型。RNA 测序分析表明，阿司匹林主要通过调节免疫应答来缓解酒渣鼻样皮肤皮炎。在机制上，我们发现阿司匹林可减少与酒渣鼻相关的趋化因子和细胞因子的产生，并抑制 LL37 诱导的酒渣鼻样小鼠中 Th1 和 Th17 极化免疫应答。此外，阿司匹林给药可降低酒渣鼻样皮肤中的微血管密度和 VEGF 表达。我们进一步证明，阿司匹林可抑制 NF-κB 信号的激活及其下游促炎细胞因子的释放。综上，我们表明阿司匹林通过减轻皮肤炎症和血管生成对酒渣鼻发挥治疗作用，提示其可能成为治疗酒渣鼻的一种有前途的治疗候选药物。
