Pritchett C J, Senior P V, Sunter J P, Watson A J, Appleton D R, Wilson R G
Cell Tissue Kinet. 1985 May;18(3):273-7. doi: 10.1111/j.1365-2184.1985.tb00657.x.
Organ culture, using human colorectal mucosa and tumours, is a good system in which to test a new stathmokinetic agent such as vindesine. Using this system we have found that vindesine has similar metaphase-arresting properties to vincristine, including at least a 6-fold dose response difference in its ability to arrest mitosis in mucosa and tumour, mucosa being the more sensitive. Vindesine is a satisfactory stathmokinetic agent, but in view of its greater cost offers no particular advantages over vincristine.
利用人结肠黏膜和肿瘤进行器官培养，是测试一种新的有丝分裂抑制剂（如长春地辛）的良好系统。通过该系统我们发现，长春地辛与长春新碱具有相似的中期阻滞特性，包括在黏膜和肿瘤中阻滞有丝分裂能力的剂量反应差异至少为6倍，黏膜更为敏感。长春地辛是一种令人满意的有丝分裂抑制剂，但鉴于其成本更高，与长春新碱相比并无特别优势。
