Wang Gang, Pan Shengjie
Department of General Surgery, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Suzhou City, Jiangsu Province, China.
Department of Neurology, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Suzhou City, Jiangsu Province, China.
J Cancer Res Clin Oncol. 2025 Jan 27;151(2):50. doi: 10.1007/s00432-025-06093-1.
To investigate the synergistic effects of combined sleep interventions and enhanced nutritional support on postoperative recovery in colon cancer patients, with a focus on sleep quality, nutritional status, pain management, psychological well-being, and quality of life.
This randomized controlled trial included 290 postoperative colon cancer patients admitted to the First Affiliated Hospital of Soochow University between May 2021 and May 2023. Participants were randomized into two groups: the intervention group, which received standard care supplemented with sleep and nutritional interventions, and the control group, which received standard care alone. Outcomes were assessed pre- and post-intervention, including the Pittsburgh Sleep Quality Index (PSQI), nutritional markers (serum albumin, prealbumin, body weight, etc.), Visual Analog Scale (VAS) for pain, Self-Rating Anxiety and Depression Scales (SAS, SDS), and EORTC QLQ-C30 quality of life scores.
The intervention group demonstrated significantly greater improvements across all assessed domains compared to the control group ( P < 0.005 after Bonferroni correction). Sleep quality (PSQI: 7.81 vs. 10.43, d = 0.81) and nutritional markers (e.g., prealbumin: 230.19 mg/L vs. 188.01 mg/L, d = 1.21 ) improved markedly. Similarly, reductions in pain (VAS: 2.65 vs. 5.19,d = 1.09 ), anxiety (SAS: 42.03 vs. 49.45, d = 0.88), and depression (SDS: 38.17 vs. 49.77,d = 1.02 ) were observed. Quality of life scores significantly increased in the intervention group compared to the control group (EORTC QLQ-C30: 99.29 vs. 88.41, d = 0.92).
The combined intervention of sleep enhancement and nutritional support significantly accelerated postoperative recovery in colon cancer patients, demonstrating synergistic effects that improved physical, psychological, and quality-of-life outcomes. These findings underscore the value of integrating multifaceted interventions into standard postoperative care to optimize recovery trajectories and overall well-being.
探讨联合睡眠干预和强化营养支持对结肠癌患者术后恢复的协同作用，重点关注睡眠质量、营养状况、疼痛管理、心理健康和生活质量。
这项随机对照试验纳入了2021年5月至2023年5月期间在苏州大学附属第一医院住院的290例结肠癌术后患者。参与者被随机分为两组：干预组接受标准护理并辅以睡眠和营养干预，对照组仅接受标准护理。在干预前后评估结果，包括匹兹堡睡眠质量指数（PSQI）、营养指标（血清白蛋白、前白蛋白、体重等）、疼痛视觉模拟量表（VAS）、自评焦虑量表和抑郁量表（SAS、SDS）以及欧洲癌症研究与治疗组织生活质量核心问卷（EORTC QLQ-C30）评分。
与对照组相比，干预组在所有评估领域均有显著更大的改善（Bonferroni校正后P < 0.005）。睡眠质量（PSQI：7.81对10.43，d = 0.81）和营养指标（如前白蛋白：230.19mg/L对188.01mg/L，d = 1.21）明显改善。同样，疼痛（VAS：2.65对5.19，d = 1.09）、焦虑（SAS：42.03对49.45，d = 0.88）和抑郁（SDS：38.17对49.77，d = 1.02）也有所减轻。与对照组相比，干预组的生活质量评分显著提高（EORTC QLQ-C30：99.29对88.41，d = 0.92）。
改善睡眠和营养支持的联合干预显著加速了结肠癌患者的术后恢复，显示出协同作用，改善了身体、心理和生活质量结局。这些发现强调了将多方面干预措施纳入标准术后护理以优化恢复轨迹和整体健康状况的价值。
