Gao Yahui, Liu George E, Ma Li, Li Cong-Jun, Baldwin Ransom L
Animal Genomics and Improvement Laboratory, BARC, Agricultural Research Service, USDA, Beltsville, MD, 20705, USA.
Department of Animal and Avian Sciences, University of Maryland, College Park, MD, 20742, USA.
BMC Genom Data. 2025 Jan 27;26(1):9. doi: 10.1186/s12863-025-01295-5.
As one of the most important ruminant breeds, Holstein cattle supply a significant portion of milk and dairy for human consumption, playing a crucial role in agribusiness. The goal of our study was to examine the molecular adaptation of gastrointestinal tissues that facilitate milk synthesis in dairy cattle. DATA DESCRIPTION: We performed RNA-seq analysis on epithelial cells from the rumen, duodenum, and colon at eight different time points: Days 3, 14, 28, 45, 120, 220, and 305 in milk, as well as the dry period. Samples were taken from five multiparous dairy cows as biological replicates per tissue per stage, except for Days 14 and 28, for which the sample size was three. These tissues each serve critical and distinct roles in the digestion and absorption of nutrients and are all vital for providing the necessary substrates required for milk production. Understanding the intricate connections between the tissues involved in providing nutrients necessary to support milk synthesis and their role in digestion can deepen the understanding of lactation physiology. This resource aims to deliver in-depth insights into cattle lactation, highlighting the distinct traits of gastrointestinal tissues and illuminating the intricate transcriptomic dynamics throughout the lactation period.
作为最重要的反刍动物品种之一，荷斯坦奶牛为人类消费提供了很大一部分牛奶和乳制品，在农业综合企业中发挥着关键作用。我们研究的目的是检查促进奶牛产奶的胃肠道组织的分子适应性。数据描述：我们在八个不同时间点对瘤胃、十二指肠和结肠的上皮细胞进行了RNA测序分析，这些时间点分别是产奶第3天、14天、28天、45天、120天、220天和305天，以及干奶期。除了第14天和第28天样本量为3头外，每个阶段每个组织均从5头经产奶牛中采集样本作为生物学重复。这些组织在营养物质的消化和吸收中各自发挥着关键且独特的作用，并且对于提供产奶所需的必要底物都至关重要。了解参与提供支持产奶所需营养物质的组织之间的复杂联系及其在消化中的作用，可以加深对泌乳生理学的理解。本资源旨在深入洞察奶牛泌乳情况，突出胃肠道组织的独特特征，并阐明整个泌乳期复杂的转录组动态变化。
