Girsang Rodman Tarigan, Rusmil Kusnandi, Fadlyana Eddy, Setiabudiawan Budi, Adrizain Riyadi, Mulyadi Rizky Perdana, Budiman Arief, Utami Rona Kania, Mardiah Behesti Zahra, Dwi Putra Muhammad Gilang, Fulendry Frizka Primadewi, Nashsyah Dinda Tiaraningrum, Sukandar Hadyana
Child Health Department, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.
Faculty of Medicine, President University, Bekasi, Indonesia.
BMC Infect Dis. 2025 Jan 27;25(1):124. doi: 10.1186/s12879-025-10453-0.
Hand, foot, and mouth disease (HFMD) is an infectious disease that often affects children under 5 years of age. Over the past 20 years, enterovirus 71 (EV71) has become a major concern among children, especially in the Asia-Pacific region. Currently, there are no data showing the seroprevalence of HMFDs in Indonesia. This study aimed to determine the seroprevalence of antibodies to EV71 infection in rural and urban areas.
This study was an observational analysis and cross-sectional seroprevalence survey of HFMD in children aged 6 to 71 months. The sampling locations were the Padalarang health centre, which is rural, and the Garuda health centre, which is urban. The total sample included 600 children aged 6-71 months from these two locations. Blood sample testing uses enzyme-linked immunosorbent assays (ELISAs) to identify subjects who are positive for IgG EV71 and the risk factors that may influence it.
In total, 596 subjects (99.3%) were positive for the seroprevalence of EV71 IgG in rural and urban areas. Child age, sex, nutritional status, height/age, immunisation status, parental income, and father's and mother's educations were not statistically related in rural and urban areas (p > 0.05) because the rate of IgG EV71 seropositivity was very high.
This study revealed that the rate of IgG EV71 HFMD seropositivity in Indonesia, especially in the Padalarang health centre and Garuda health centre, was very high. Further research is needed to investigate HFMD cases because of the lack of attention given to this disease and the need to consider whether immunisation is necessary to prevent HFMD.
This study is registered at clinicaltrials.gov, National Clinical Trial (NCT) No. NCT05637229.
手足口病（HFMD）是一种常影响5岁以下儿童的传染病。在过去20年里，肠道病毒71型（EV71）已成为儿童中的一个主要关注点，尤其是在亚太地区。目前，尚无数据显示印度尼西亚手足口病的血清流行率。本研究旨在确定农村和城市地区EV71感染抗体的血清流行率。
本研究是一项针对6至71个月大儿童手足口病的观察性分析和横断面血清流行率调查。抽样地点为农村的帕达拉朗健康中心和城市的加鲁达健康中心。总样本包括来自这两个地点的600名6 - 71个月大的儿童。血液样本检测采用酶联免疫吸附测定（ELISA）来识别EV71 IgG阳性的受试者以及可能影响其的危险因素。
总体而言，农村和城市地区共有596名受试者（99.3%）EV71 IgG血清流行率呈阳性。儿童年龄、性别、营养状况、身高/年龄、免疫接种状况、父母收入以及父母的教育程度在农村和城市地区均无统计学关联（p > 0.05），因为EV71 IgG血清阳性率非常高。
本研究表明，印度尼西亚，特别是在帕达拉朗健康中心和加鲁达健康中心，EV71手足口病IgG血清阳性率非常高。由于对该疾病缺乏关注以及需要考虑是否有必要进行免疫接种以预防手足口病，因此需要进一步研究来调查手足口病病例。
本研究已在clinicaltrials.gov注册，国家临床试验（NCT）编号为NCT05637229。
