Hurley Caitlin R, Winters John, McAlpine Melanie, Ng Michelle, Anthonappa Robert P
Paediatric Dentistry, The University of Western Australia, Dental School, Perth, Australia.
Department of Paediatric Dentistry, Perth Children's Hospital, Nedlands, Australia.
Spec Care Dentist. 2025 Jan-Feb;45(1):e13106. doi: 10.1111/scd.13106.
Aplastic anemia (AA) is a rare condition that frequently manifests with pancytopenia. Management of severe disease is through either allogenic stem cell transplantation or immunosuppressive therapy with supportive care. Drug-induced gingival overgrowth (DIGO) is a potential complication of a number of medications, including cyclosporine and amlodipine.
The following report presents the case of a male child who was diagnosed with severe AA at 7 years of age. He was managed with immunosuppressive therapy and developed DIGO as a side effect of treatment, exacerbated by poor oral hygiene. Nonsurgical and surgical management strategies were utilized. Gingival debulking surgery was completed at 9 years of age, once the patient's condition had stabilized. Postoperative care included regular dental prophylaxis and oral hygiene instruction. The patient's medical condition remained stable, and his oral health was maintained without relapse of DIGO.
This case emphasizes the importance of coordinated care for managing DIGO in immunocompromised pediatric patients and describes the successful management of DIGO using both nonsurgical and surgical methods.
再生障碍性贫血（AA）是一种罕见疾病，常表现为全血细胞减少。重症患者的治疗方法包括异基因干细胞移植或免疫抑制治疗并辅以支持治疗。药物性牙龈增生（DIGO）是包括环孢素和氨氯地平在内的多种药物的潜在并发症。
以下报告介绍了一名7岁男性儿童被诊断为重症AA的病例。他接受免疫抑制治疗，出现DIGO作为治疗副作用，口腔卫生不良使其加重。采用了非手术和手术管理策略。患者病情稳定后，9岁时完成了牙龈减容手术。术后护理包括定期口腔预防保健和口腔卫生指导。患者的病情保持稳定，口腔健康得以维持，DIGO未复发。
本病例强调了免疫功能低下的儿科患者管理DIGO时协调护理的重要性，并描述了使用非手术和手术方法成功管理DIGO的情况。
