Department of Plastic Surgery, Salvator Mundi International Hospital, Roma, Italy.
Clin Interv Aging. 2010 Nov 9;5:317-22. doi: 10.2147/CIA.S13813.
The continual search for new products for soft-tissue augmentation has in recent years led to the introduction of long lasting alternatives to hyaluronic acids and collagen that are composed of other polymers able to improve clinical persistence over time. This is the first report in which sodium carboxymethyl cellulose (CMC) has been chemically treated by the cross-linking process and thus used as a hydrogel for soft-tissue augmentation through injection with thin needles. The study evaluates, from a clinical point of view, the behavior of cross-linked carboxymethyl cellulose hydrogel used in the aesthetic field and its side effects so as to check the safety and performance of the polymer following intradermal injections.
This work shows the preliminary results of an ongoing clinical study conducted between 2006 and 2009, performed on 84 healthy volunteers (62 females, 22 males) aged between 18 and 72 years, for the treatment of 168 nasolabial folds, 45 perioral wrinkles, and 39 lip volume.
Study results show an excellent correction of facial defects. Tolerance and aesthetic quality of the correction obtained indicate considerable safety features and absence of side effects. From a clinical point of view, hydrogel is gradually absorbed into the injection site without migration issues.
Cross-linked CMC hydrogel proves to be an ideal agent for soft tissue augmentation with regard to safety and ease of application. It did not cause infection, extrusion, migration, or adverse reactions in the patients who have been followed for two years. Delayed aesthetic results on facial wrinkles were very satisfactory.
近年来，为了寻找软组织填充的新产品，人们一直在研究其他聚合物，这些聚合物可以替代透明质酸和胶原蛋白，并且具有更好的临床持久性。本文首次报道了羧甲基纤维素钠（CMC）经过化学交联处理后，作为一种水凝胶，通过细针注射用于软组织填充的情况。本研究从临床角度评估了交联羧甲基纤维素水凝胶在美容领域的应用及其副作用，以检查聚合物在皮内注射后的安全性和性能。
本研究展示了 2006 年至 2009 年期间进行的一项正在进行的临床研究的初步结果，共纳入 84 名健康志愿者（62 名女性，22 名男性），年龄 18-72 岁，用于治疗 168 例鼻唇沟、45 例口周皱纹和 39 例唇部容量不足。
研究结果显示，该水凝胶对面部缺陷有极好的矫正作用。良好的组织相容性和矫正的美学质量表明该水凝胶具有较高的安全性，无不良反应。从临床角度来看，水凝胶逐渐被注射部位吸收，无迁移问题。
交联 CMC 水凝胶是一种理想的软组织填充剂，具有良好的安全性和易用性。在两年的随访中，该水凝胶未引起感染、挤出、迁移或不良反应。对于面部皱纹，其延迟的美学效果非常满意。
