Song Tongxing, Qi Ming, Zhu Yucheng, Wang Nan, Liu Zhibo, Li Na, Yang Jiacheng, Han Yanxu, Wang Jing, Tao Shiyu, Ren Zhuqing, Yin Yulong, Zheng Jinshui, Tan Bie
College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan 410000, China.
Life Metab. 2024 Jan 17;3(2):load052. doi: 10.1093/lifemeta/load052. eCollection 2024 Apr.
Postnatal growth retardation (PGR) frequently occurs during early postnatal development of piglets and induces high mortality. To date, the mechanism of PGR remains poorly understood. Adipose tissue-derived microbes have been documented to be associated with several disorders of metabolism and body growth. However, the connection between microbial disturbance of adipose tissue and pig PGR remains unclear. Here, we investigated piglets with PGR and found that the adipose tissue of PGR piglets was characterized by metabolism impairment, adipose abnormality, and specific enrichment of culturable bacteria from . Gavage of , a species of genus from the , induced PGR in piglets. Moreover, this bacterium could also lead to metabolic disorders and susceptibility to acute stress, resulting in weight loss in mice. Mechanistically, multi-omics analysis indicated the changes in lipid metabolism as a response of adipose tissue to abnormal microbial composition. Further experimental tests proved that one of the altered lipids phosphatidylethanolamines could rescue the metabolism disorder and growth retardation, thereby suppressing the amount of in the adipose tissue. Together, these results highlight that the microbe-host crosstalk may regulate the metabolic function of adipose tissue in response to PGR.
产后生长迟缓（PGR）在仔猪出生后的早期发育阶段频繁发生，并导致高死亡率。迄今为止，PGR的机制仍知之甚少。有文献记载，脂肪组织衍生的微生物与多种代谢紊乱和身体生长有关。然而，脂肪组织的微生物紊乱与仔猪PGR之间的联系仍不清楚。在此，我们对患有PGR的仔猪进行了研究，发现PGR仔猪的脂肪组织具有代谢受损、脂肪异常以及来自[具体来源未明确]的可培养细菌的特异性富集等特征。用来自[具体属]属的一种[具体菌种]对仔猪进行灌胃，可诱导仔猪出现PGR。此外，这种细菌还可导致代谢紊乱和对急性应激的易感性，致使小鼠体重减轻。从机制上讲，多组学分析表明脂质代谢的变化是脂肪组织对异常微生物组成的一种反应。进一步的实验测试证明，一种改变的脂质磷脂酰乙醇胺可以挽救代谢紊乱和生长迟缓，从而抑制脂肪组织中[具体物质未明确]的量。总之，这些结果突出表明，微生物与宿主之间的相互作用可能会调节脂肪组织的代谢功能以应对PGR。
