Montoya-Estrada Araceli, García-Cerda María Valeria, Guzmán-Grenfell Alberto Martin, Figueroa-Damian Ricardo, Torres-Cosme José Luis, Laresgoiti-Servitje Estibalitz, Beltrán-Montoya Jesús Jorge, Romo-Yañez José, Reyes-Muñoz Enrique
Coordination of Gynecological and Perinatal Endocrinology, National Institute of Perinatology Isidro Espinosa de los Reyes, Mexico City, MEX.
Department of Immunobiochemistry, National Institute of Perinatology Isidro Espinosa de los Reyes, Mexico City, MEX.
Cureus. 2024 Dec 28;16(12):e76516. doi: 10.7759/cureus.76516. eCollection 2024 Dec.
Allostatic load and oxidative stress (OS) markers differ in women with and without preeclampsia. However, there is no difference in allostatic load and OS markers between late-onset preeclampsia (L-OP) and early-onset preeclampsia (E-OP). This study aimed to compare the concentrations of allostatic load and OS markers in pregnant women with L-OP and E-OP.
This was a comparative cross-sectional study. Women with single pregnancy and a diagnosis of preeclampsia were included. Women with multiple pregnancies and/or chronic hypertension were excluded. Group 1 included women with E-OP (n=16), Group 2 included women with L-OP (n=45), and Group 3 included women without preeclampsia (n=40).
No statistical differences were found in maternal age, body mass index, or number of gestations. Arginase levels were higher in Group 1 compared to Group 2 (p = 0.04) and Group 1 compared to Group 3 (p = 0.01). Total antioxidative capacity was higher in Group 1 compared to Group 2 (p = 0.03) and Group 1 compared to Group 3 (p = 0.001). Malondialdehyde levels were higher in Group 1 compared to Group 2 (p = 0.001) and Group 1 compared to Group 3 (p = 0.001). Total sulfhydryl compounds were lower in Group 1 compared to Group 2 (p = 0.01) and Group 1 compared to Group 3 (p = 0.001). No differences were observed between study groups in allostatic load markers.
Higher levels of OS markers were found in women with E-OP compared to women with L-OP and controls.
有子痫前期和无子痫前期的女性，其应激负荷和氧化应激（OS）标志物存在差异。然而，晚发型子痫前期（L-OP）和早发型子痫前期（E-OP）之间的应激负荷和OS标志物并无差异。本研究旨在比较L-OP和E-OP孕妇的应激负荷和OS标志物浓度。
这是一项比较性横断面研究。纳入单胎妊娠且诊断为子痫前期的女性。排除多胎妊娠和/或慢性高血压女性。第1组包括E-OP女性（n = 16），第2组包括L-OP女性（n = 45），第3组包括无子痫前期女性（n = 40）。
在产妇年龄、体重指数或妊娠次数方面未发现统计学差异。与第2组相比，第1组的精氨酸酶水平更高（p = 0.04），与第3组相比，第1组的精氨酸酶水平也更高（p = 0.01）。与第2组相比，第1组的总抗氧化能力更高（p = 0.03），与第3组相比，第1组的总抗氧化能力也更高（p = 0.001）。与第2组相比，第1组的丙二醛水平更高（p = 0.001），与第3组相比，第1组的丙二醛水平也更高（p = 0.001）。与第2组相比，第1组的总巯基化合物水平更低（p = 0.01），与第3组相比，第1组的总巯基化合物水平也更低（p = 0.001）。各研究组在应激负荷标志物方面未观察到差异。
与L-OP女性和对照组相比，E-OP女性的OS标志物水平更高。
