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The secret of youth: how is systemic rejuvenation achieved at the single cell level?

作者信息

Wang Lingna, Liu Jiaqing, Liu Huicong, Yazawa Masayuki, Zhu Fangfang

机构信息

School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.

Department of Rehabilitation and Regenerative Medicine, Columbia University, New York, NY 10032, USA.

出版信息

Life Med. 2022 Jun 28;1(3):258-260. doi: 10.1093/lifemedi/lnac018. eCollection 2022 Dec.

DOI:10.1093/lifemedi/lnac018
PMID:39872748
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11749769/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6919/11749769/d7520cc066d1/lnac018_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6919/11749769/b54cafdd7e38/lnac018_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6919/11749769/d7520cc066d1/lnac018_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6919/11749769/b54cafdd7e38/lnac018_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6919/11749769/d7520cc066d1/lnac018_fig2.jpg

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本文引用的文献

1
Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues.异时共生诱导干细胞更新和衰老组织的全身性年轻化。
Cell Stem Cell. 2022 Jun 2;29(6):990-1005.e10. doi: 10.1016/j.stem.2022.04.017. Epub 2022 May 24.
2
Molecular hallmarks of heterochronic parabiosis at single-cell resolution.单细胞分辨率下异时共生的分子特征
Nature. 2022 Mar;603(7900):309-314. doi: 10.1038/s41586-022-04461-2. Epub 2022 Mar 2.
3
An aged immune system drives senescence and ageing of solid organs.衰老的免疫系统导致实体器官衰老和衰老。
Nature. 2021 Jun;594(7861):100-105. doi: 10.1038/s41586-021-03547-7. Epub 2021 May 12.
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Age-associated changes in human hematopoietic stem cells.人类造血干细胞中与年龄相关的变化。
Semin Hematol. 2017 Jan;54(1):39-42. doi: 10.1053/j.seminhematol.2016.10.004. Epub 2016 Oct 20.
5
β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis.β2微球蛋白是一种全身性促衰老因子,会损害认知功能和神经发生。
Nat Med. 2015 Aug;21(8):932-7. doi: 10.1038/nm.3898. Epub 2015 Jul 6.
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Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors.年轻系统因素对衰老小鼠大脑的血管和神经再生作用。
Science. 2014 May 9;344(6184):630-4. doi: 10.1126/science.1251141. Epub 2014 May 5.
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Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy.生长分化因子 11 是一种循环因子,可逆转与年龄相关的心肌肥厚。
Cell. 2013 May 9;153(4):828-39. doi: 10.1016/j.cell.2013.04.015.
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The ageing systemic milieu negatively regulates neurogenesis and cognitive function.衰老的全身环境会负向调节神经发生和认知功能。
Nature. 2011 Aug 31;477(7362):90-4. doi: 10.1038/nature10357.
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Rejuvenation of aged progenitor cells by exposure to a young systemic environment.通过暴露于年轻的全身环境使衰老祖细胞恢复活力。
Nature. 2005 Feb 17;433(7027):760-4. doi: 10.1038/nature03260.
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Parabiosis between old and young rats.老年与幼年大鼠联体共生实验。
Gerontologia. 1957;1(1):7-17. doi: 10.1159/000210677.