Chan W Y, Tam P P, So K C, Yeung H W
Contraception. 1985 Jan;31(1):83-90. doi: 10.1016/0010-7824(85)90077-0.
beta-Momorcharin purified from the seeds of Momordica charantia L. suppressed the decidual response of pseudopregnant mouse uterus to mechanical stimulus. In the beta-momorcharin-treated uterus, stromal cells failed to decidualise, uterine glands distended, and a diminished cell proliferation was found in the endometrium and myometrium. beta-Momorcharin also inhibited the biosynthetic activity of the cultured endometrial cells. The rate of incorporation of 3H-thymidine, 3H-uridine and 3H-leucine was all depressed by beta-momorcharin. The termination of the early pregnancy in the mouse may have resulted from an inhibitory effect of the abortifacient protein on the differentiating endometrium.
从苦瓜种子中纯化得到的β-苦瓜素可抑制假孕小鼠子宫对机械刺激的蜕膜反应。在经β-苦瓜素处理的子宫中，基质细胞未能蜕膜化，子宫腺扩张，且子宫内膜和肌层中的细胞增殖减少。β-苦瓜素还抑制培养的子宫内膜细胞的生物合成活性。β-苦瓜素使3H-胸腺嘧啶核苷、3H-尿苷和3H-亮氨酸的掺入率均降低。小鼠早期妊娠的终止可能是由于堕胎蛋白对分化中的子宫内膜的抑制作用所致。
