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Action of alpha-momorcharin, a ribosome inactivating protein, on cultured tumor cell lines.

作者信息

Ng T B, Liu W K, Sze S F, Yeung H W

机构信息

Department of Biochemistry, Faculty of Medicine, Chinese University of Hong Kong, Shatin, N.T.

出版信息

Gen Pharmacol. 1994 Jan;25(1):75-7. doi: 10.1016/0306-3623(94)90012-4.

DOI:10.1016/0306-3623(94)90012-4
PMID:8026716
Abstract
  1. alpha-Momorcharin, a glycoprotein isolated from seeds of the bitter gourd, Momordica charantia inhibited incorporation of [3H]thymidine, [3H]leucine and [3H]uridine into P388 (mouse monocyte-macrophage), J774 (Balb/c macrophage), JAR (human placental choriocarcinoma) and sarcoma S180 cell lines. 2. The most potent inhibitory effect was exerted on P388 cells and the smallest effect on sarcoma cells. 3. alpha-Momorcharin also enhanced the tumoricidal effect of mouse macrophages on mouse mastocytomal (P815) cells.
摘要

相似文献

1
Action of alpha-momorcharin, a ribosome inactivating protein, on cultured tumor cell lines.
Gen Pharmacol. 1994 Jan;25(1):75-7. doi: 10.1016/0306-3623(94)90012-4.
2
The inhibitory effects of beta-momorcharin on endometrial cells in the mouse.β-苦瓜素对小鼠子宫内膜细胞的抑制作用。
Contraception. 1985 Jan;31(1):83-90. doi: 10.1016/0010-7824(85)90077-0.
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beta-Momorcharin, a plant glycoprotein, inhibits synthesis of macromolecules in embryos, splenocytes and tumor cells.β-苦瓜素是一种植物糖蛋白，可抑制胚胎、脾细胞和肿瘤细胞中大分子的合成。
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Trichosanthin, alpha-momorcharin and beta-momorcharin: identity of abortifacient and ribosome-inactivating proteins.天花粉蛋白、α-苦瓜素和β-苦瓜素：堕胎蛋白与核糖体失活蛋白的一致性
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Characterization of the enzymatic mechanism of gamma-momorcharin, a novel ribosome-inactivating protein with lower molecular weight of 11,500 purified from the seeds of bitter gourd (Momordica charantia).γ-苦瓜素是一种从苦瓜（Momordica charantia）种子中纯化得到的分子量为11,500的新型核糖体失活蛋白，对其酶促机制的表征。
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Alpha-momorcharin (α-MMC) exerts effective anti-human breast tumor activities but has a narrow therapeutic window in vivo.α-苦瓜素（α-MMC）具有有效的抗人乳腺肿瘤活性，但在体内的治疗窗较窄。
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The immunosuppressive activities of two abortifacient proteins isolated from the seeds of bitter melon (Momordica charantia).从苦瓜（苦瓜属）种子中分离出的两种堕胎蛋白的免疫抑制活性。
Immunopharmacology. 1987 Jun;13(3):159-71. doi: 10.1016/0162-3109(87)90054-3.
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Inhibition of macromolecular synthesis in P388 mouse leukemia ascites cells by bouvardin (NSC 259968).
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The termination of early pregnancy in the mouse by beta-momorcharin.β-苦瓜素对小鼠早期妊娠的终止作用。
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Ribosome inactivating protein and lectin from bitter melon (Momordica charantia) seeds: sequence comparison with related proteins.苦瓜（苦瓜属）种子中的核糖体失活蛋白和凝集素：与相关蛋白的序列比较
Biochem Biophys Res Commun. 1998 Dec 9;253(1):143-6. doi: 10.1006/bbrc.1998.9765.

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