α-苦瓜素、β-苦瓜素和α-天花粉蛋白对体外脂肪生成、睾丸和肾上腺类固醇生成以及体内血糖水平的影响。

Effects of alpha-momorcharin, beta-momorcharin and alpha-trichosanthin on lipogenesis and testicular and adrenal steroidogenesis in vitro and plasma-glucose levels in vivo.

作者信息

Ng T B, Hon W K, Lo L H, Li W W, Yeung H W

出版信息

J Ethnopharmacol. 1986 Oct;18(1):45-53. doi: 10.1016/0378-8741(86)90042-5.

Abstract

The effects of alpha-momorcharin, beta-momorcharin and alpha-trichosanthin on lipogenesis in isolated rat adipocytes were examined. None of the three abortifacient proteins possessed lipogenic activity. The plant proteins did not affect the plasma-glucose level in fasting mice nor did they affect luteinizing hormone-induced testosterone production in isolated rat Leydig cells or corticotropin-induced corticosterone production in isolated rat adrenal decapsular cells by the end of a 2-h incubation period. The results suggest that the functions of adipocytes, adrenal decapsular cells, Leydig cells and pancreatic beta cells were not greatly affected after short-term exposure to the abortifacient proteins.

摘要

研究了α-苦瓜素、β-苦瓜素和α-天花粉蛋白对分离的大鼠脂肪细胞脂肪生成的影响。这三种堕胎蛋白均不具有脂肪生成活性。在2小时的孵育期结束时，这些植物蛋白既不影响禁食小鼠的血糖水平，也不影响促黄体生成素诱导的分离大鼠睾丸间质细胞睾酮生成或促肾上腺皮质激素诱导的分离大鼠肾上腺被膜细胞皮质酮生成。结果表明，短期暴露于堕胎蛋白后，脂肪细胞、肾上腺被膜细胞、睾丸间质细胞和胰腺β细胞的功能未受到很大影响。