Hassan Muhammad Muneeb, Sikandar Sheikh Muhammad, Jamal Farrukh, Ameeq Muhammad, Kargbo Alpha
Department of Statistics The Islamia University of Bahawalpur Bahawalpur Pakistan.
DHQ Hospital Muzaffargarh Muzaffargarh Punjab Pakistan.
Health Sci Rep. 2025 Jan 26;8(1):e70395. doi: 10.1002/hsr2.70395. eCollection 2025 Jan.
Chronic obstructive pulmonary disease (COPD) patients commonly exhibit significant morbidity and experience a diminished quality of life. Since there has been no prior research on pneumonia in our study population, we carried out this study to learn more about the situation.
A retrospective analysis of 912 COPD patients with CAP who were receiving ICS treatment at the DHQ Hospital in Muzaffargarh, Punjab, Pakistan was conducted. Study began in February 2022 and ended in February 2023. Using multinomial logistic regression, the odds ratio and relative risk and Kaplan-Meier curves showed time-to-death and recovery by COPD status.
Patients with COPD having a smoking history from 25 pack years and above had 22.791 higher odds of CAP (95% CI: 20.413-31.515), 21.527 higher odds of HTN (95% CI: 12.323-57.103), 16.955 higher odds of diabetes (95% CI: 22.954-29.331), and 13.964 higher odds of death in severity without COVID-19 vaccination (95% CI: 5.988-32.561) compared to patients with COPD having a smoking history from 10 to 15 pack years.
COPD patients with a shorter ICS duration had a lower CAP risk, and vice versa, while vaccinated patients had a less severe disease as compared to non-vaccinated patients.
慢性阻塞性肺疾病（COPD）患者通常有明显的发病率，生活质量下降。由于此前在我们的研究人群中没有关于肺炎的研究，我们开展了这项研究以进一步了解情况。
对巴基斯坦旁遮普省木扎法尔格尔市DHQ医院接受ICS治疗的912例COPD合并社区获得性肺炎（CAP）患者进行回顾性分析。研究于2022年2月开始，2023年2月结束。使用多项逻辑回归、优势比和相对风险以及Kaplan-Meier曲线显示了按COPD状态的死亡时间和恢复情况。
与吸烟史为10至15包年的COPD患者相比，吸烟史为25包年及以上的COPD患者发生CAP的几率高22.791（95%CI：20.413 - 31.515），患高血压的几率高21.527（95%CI：12.323 - 57.103），患糖尿病的几率高16.955（95%CI：22.954 - 29.331），未接种COVID-19疫苗的重度患者死亡几率高13.964（95%CI：5.988 - 32.561）。
ICS治疗时间较短的COPD患者发生CAP的风险较低，反之亦然，且接种疫苗的患者与未接种疫苗的患者相比，疾病症状较轻。
