Wang Shih-Min, Lu Mei-Chin, Hsu Yu-Ming, Huang Chun-Chung, Fang Chih-Yuan, Yu Chuan-Hang, Chueh Pin Ju, Yu Cheng-Chia, Lee Shiao-Pieng
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung, Taiwan.
J Dent Sci. 2025 Jan;20(1):361-367. doi: 10.1016/j.jds.2024.06.016. Epub 2024 Jul 2.
BACKGROUND/PURPOSE: The extract of the soft coral has shown an anti-cancer activity in various cancer cells. However, its effect on the oral squamous cell carcinoma cell (OSCC) lines remains unclear. The purpose of this study is to investigate the anti-cancer effects of the extract of (C127) on the OSCC cells.
This study evaluated the effects of the soft coral extract of (C127) on SAS and Ca9-22 cells, cell viability, migration ability, and apoptosis. Electric cell-substrate impedance sensing (ECIS) was parallelly used on SAS cells to confirm the results.
C127 affected cell viability, morphology, and migration ability in both cell lines. In SAS cells, C127 inhibited cell viability in a dose dependent manner ( < 0.001) and induced apoptosis at 10 μg/mL ( < 0.05). In addition, C127 significantly inhibited migration ability on both cell lines in a dose-dependent manner ( < 0.001).
This study illustrated the potential of marine-derived compounds of on its activity against OSCC cells.
背景/目的：软珊瑚提取物已在多种癌细胞中显示出抗癌活性。然而，其对口腔鳞状细胞癌细胞（OSCC）系的作用仍不清楚。本研究的目的是探讨（C127）提取物对OSCC细胞的抗癌作用。
本研究评估了（C127）软珊瑚提取物对SAS和Ca9-22细胞、细胞活力、迁移能力和凋亡的影响。在SAS细胞上平行使用电细胞基质阻抗传感（ECIS）来证实结果。
C127影响两种细胞系的细胞活力、形态和迁移能力。在SAS细胞中，C127以剂量依赖性方式抑制细胞活力（<0.001），并在10μg/mL时诱导凋亡（<0.05）。此外，C127以剂量依赖性方式显著抑制两种细胞系的迁移能力（<0.001）。
本研究阐明了海洋来源化合物（C127）对OSCC细胞的抗癌活性潜力。
