Key Laboratory of Big Data Mining and Precision Drug Design of Guangdong Medical University, Key Laboratory of Computer-Aided Drug Design of Dongguan City, Key Laboratory for Research and Development of Natural Drugs of Guangdong Province, School of Pharmacy, Guangdong Medical University, No. 1 Xincheng Road, Dongguan 523808, China.
Centre for Cellular & Molecular Biology (CCMB), Hyderabad 500 007, India.
Mar Drugs. 2022 Aug 18;20(8):528. doi: 10.3390/md20080528.
Marine natural products are potent and promising sources of drugs among other natural products of plant, animal, and microbial origin. To date, 20 drugs from marine sources are in clinical use. Most approved marine compounds are antineoplastic, but some are also used for chronic neuropathic pain, for heparin overdosage, as haptens and vaccine carriers, and for omega-3 fatty-acid supplementation in the diet. Marine drugs have diverse structural characteristics and mechanisms of action. A considerable increase in the number of marine drugs approved for clinical use has occurred in the past few decades, which may be attributed to increasing research on marine compounds in laboratories across the world. In the present manuscript, we comprehensively studied all marine drugs that have been successfully used in the clinic. Researchers and clinicians are hopeful to discover many more drugs, as a large number of marine natural compounds are being investigated in preclinical and clinical studies.
海洋天然产物是除植物、动物和微生物来源的其他天然产物之外具有潜力和前景的药物来源。迄今为止，有 20 种源于海洋的药物正在临床应用中。大多数已批准的海洋化合物是抗肿瘤药物，但也有一些用于治疗慢性神经性疼痛、肝素过量、作为半抗原和疫苗载体，以及用于膳食中ω-3 脂肪酸的补充。海洋药物具有多种结构特征和作用机制。在过去几十年中，临床应用批准的海洋药物数量显著增加，这可能归因于全球实验室对海洋化合物研究的增加。在本手稿中，我们全面研究了所有已成功用于临床的海洋药物。研究人员和临床医生希望能发现更多的药物，因为大量的海洋天然化合物正在进行临床前和临床研究。
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