Lin Shian-Ren, Chang Chia-Hsiang, Hsu Che-Fang, Tsai May-Jwan, Cheng Henrich, Leong Max K, Sung Ping-Jyun, Chen Jian-Chyi, Weng Ching-Feng
Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan.
Center for Prevention and Therapy of Gynaecological Cancers, Department of Research, Tzu Chi Hospital, Hualien, Taiwan.
Br J Pharmacol. 2020 Mar;177(6):1409-1423. doi: 10.1111/bph.14816. Epub 2019 Nov 27.
Traditional chemotherapy is being considered due to hindrances caused by systemic toxicity. Currently, the administration of multiple chemotherapeutic drugs with different biochemical/molecular targets, known as combination chemotherapy, has attained numerous benefits like efficacy enhancement and amelioration of adverse effects that has been broadly applied to various cancer types. Additionally, seeking natural-based alternatives with less toxicity has become more important. Experimental evidence suggests that herbal extracts such as Solanum nigrum and Claviceps purpurea and isolated herbal compounds (e.g., curcumin, resveratrol, and matairesinol) combined with antitumoral drugs have the potential to attenuate resistance against cancer therapy and to exert chemoprotective actions. Plant products are not free of risks: Herb adverse effects, including herb-drug interactions, should be carefully considered. LINKED ARTICLES: This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc.
由于全身毒性造成的阻碍，正在考虑采用传统化疗。目前，使用具有不同生化/分子靶点的多种化疗药物进行联合化疗已取得诸多益处，如提高疗效和改善不良反应，这已广泛应用于各种癌症类型。此外，寻找毒性较小的天然替代物变得更加重要。实验证据表明，龙葵和麦角菌等草药提取物以及分离出的草药化合物（如姜黄素、白藜芦醇和罗汉松脂素）与抗肿瘤药物联合使用，有可能减轻对癌症治疗的耐药性并发挥化学保护作用。植物产品并非没有风险：草药的不良反应，包括草药与药物的相互作用，都应仔细考虑。相关文章：本文是关于营养保健品药理学主题部分的一部分。要查看本节中的其他文章，请访问http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc。
