Yao Chuying, Yuan Yue, Du Guangyan, Li Quan, Ji Yutian
College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China.
Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P. R. China.
J Mater Chem B. 2025 Feb 19;13(8):2826-2833. doi: 10.1039/d4tb02058h.
Chinese herbal medicine (CHM) has offered a great treasure and source of inspiration for developing innovative medicinal materials and therapy. In this work, inspired by the macroscopic compatibility of and in CHM, the puerarin (PUE) and CaSO (Ca) as the main constituents, respectively, from the two herbs are co-assembled into two-component molecular hydrogels. Such two-component gels exhibited enhanced mechanical properties compared with the single-component PUE gel due to the introduction of crosslinking hydrogen bonds between PUE and Ca. Importantly, the two-component gels show good biocompatibility and antibacterial and antioxidant properties. Moreover, wound healing experiments on an -infected mouse model together with the histological and immunological analyses were conducted, revealing that the two-component gels possessed good wound-healing-promoting functions. Our research shows how the medication practice of CHM can contribute to the development of novel bio-soft materials. It is anticipated that more herbal medicine-inspired medicinal materials will be built and tailored for specific bio-applications.
中草药为开发创新药物材料和疗法提供了巨大的宝库和灵感来源。在这项工作中，受中草药中[两种草药名称缺失]宏观配伍的启发，分别从这两种草药中提取的主要成分葛根素（PUE）和硫酸钙（Ca）共组装成二元分子水凝胶。由于PUE和Ca之间引入了交联氢键，这种二元凝胶与单组分PUE凝胶相比表现出增强的机械性能。重要的是，二元凝胶具有良好的生物相容性、抗菌和抗氧化性能。此外，对感染[感染类型缺失]的小鼠模型进行了伤口愈合实验，并进行了组织学和免疫学分析，结果表明二元凝胶具有良好的促进伤口愈合的功能。我们的研究展示了中草药的用药实践如何有助于新型生物软材料的开发。预计将构建更多受草药启发的药物材料并针对特定的生物应用进行定制。
