Li Xin'ai, Wang Junhui, Wang Peng, Qi Shuo, Amalraj Jeremiah, Zhou Jingwei, Ding Zhiguo
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Tongchuan City Thyroid Disease Prevention Center, Tongchuan, China.
FASEB J. 2025 Jan 31;39(2):e70263. doi: 10.1096/fj.202401764R.
With the emergence of high-quality sequencing technologies, further research on transcriptomes has become possible. Circular RNA (circRNA), a novel type of endogenous RNA molecule with a covalently closed circular structure through "back-splicing," is reported to be widely present in eukaryotic cells and participates mainly in regulating gene and protein expression in various ways. It is becoming a research hotspot in the non-coding RNA field. CircRNA shows close relation to several varieties of autoimmune diseases (AIDs) in both the physiological and pathological level and could potentially be used clinically in terms of diagnosis and treatment. Here, we focus on reviewing the importance of circRNA in various AIDs, with the aim of establishing new biomarkers and providing novel insights into understanding the role and functions of circRNA in AIDs. Specific signaling pathways of how circular RNAs are regulated in AIDs will also be illustrated in this review.
随着高质量测序技术的出现，对转录组进行进一步研究已成为可能。环状RNA（circRNA）是一种新型的内源性RNA分子，通过“反向剪接”形成共价闭合的环状结构，据报道广泛存在于真核细胞中，主要以多种方式参与调节基因和蛋白质表达。它正成为非编码RNA领域的一个研究热点。CircRNA在生理和病理水平上均与多种自身免疫性疾病（AID）密切相关，并且在诊断和治疗方面具有潜在的临床应用价值。在此，我们着重综述circRNA在各种AID中的重要性，旨在建立新的生物标志物，并为理解circRNA在AID中的作用和功能提供新的见解。本综述还将阐述circRNA在AID中是如何被调控的具体信号通路。
