Ganorkar Saurabh B, Hadole Pranay M, Patil Mangesh R, Pardeshi Chandrakantsing V, Bobade Preeti S, Shirkhedkar Atul A, Vander Heyden Yvan
Department of Pharmaceutical Chemistry and Analysis, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur 425405 India.
Department of Pharmaceutical Chemistry and Analysis, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur 425405 India.
Int J Pharm. 2025 Mar 15;672:125278. doi: 10.1016/j.ijpharm.2025.125278. Epub 2025 Jan 26.
Deep eutectic solvents (DES) have an emerging scientific role, assisting modern pharmaceutics. They are uniquely supporting the resolution of crucial issues, such as the effective extraction and isolation of bio-actives. They act as media and catalysts for pharmaceutical drug synthesis, and as green solvents and modifiers in pharmaceutical analysis. Their role in pharmaceutical formulation and drug delivery is also up-and-coming, for instance, as alternative drug-solubilizing agents, drug stabilizers and functional additives, as therapeutic deep eutectic solvents, deep eutectic API, and monomers and reaction media for the synthesis of biomaterials for advanced drug delivery. The DES also help transforming medicinal/pharmaceutical chemistry. Although DES were described in 1918, their first pharmaceutical use is only reported in 1960. In view of their broad applicability in pharmaceutics, it may be interesting to review their history, origin, evolution, potential advantages, limitations, and specific applications as green solvents. A chronological and comparative study of the literature showed the important role of DES in green approaches for modern pharmaceuticals. The concepts, applications, and outcomes of DES in pharmaceutical analysis, formulation/drug delivery, and pharmaceutical/medicinal chemistry are presented. A comprehensive outline of the atypical applications of DES as effective green solvents in pharmaceutical bioactive extraction was assessed. Efforts to present classifications of DES explored in pharmaceuticals were also made. The present manuscript also covers computational trend, adds on commercial aspects with potential future applications of DES in pharmaceutical sciences.
深共熔溶剂（DES）在辅助现代制药方面正发挥着新的科学作用。它们在解决关键问题方面具有独特的支持作用，比如生物活性成分的有效提取和分离。它们可作为药物合成的介质和催化剂，以及药物分析中的绿色溶剂和改性剂。它们在药物制剂和药物递送方面的作用也日益凸显，例如，作为替代药物增溶剂、药物稳定剂和功能添加剂，作为治疗性深共熔溶剂、深共熔活性药物成分，以及用于合成先进药物递送生物材料的单体和反应介质。深共熔溶剂还有助于变革药物化学/制药化学。尽管深共熔溶剂于1918年被描述，但它们在制药领域的首次应用直到1960年才被报道。鉴于它们在制药领域的广泛适用性，回顾其历史、起源、演变、潜在优势、局限性以及作为绿色溶剂的具体应用可能会很有意思。对文献进行的按时间顺序和比较性研究表明，深共熔溶剂在现代制药的绿色方法中发挥着重要作用。介绍了深共熔溶剂在药物分析、制剂/药物递送以及药物化学/制药化学方面的概念、应用和成果。评估了深共熔溶剂作为有效绿色溶剂在药物生物活性成分提取中的非典型应用的全面概述。还努力对制药领域中探索的深共熔溶剂分类进行了介绍。本手稿还涵盖了计算趋势，增加了商业方面的内容以及深共熔溶剂在制药科学中的潜在未来应用。
