Li Yanli, Fernández Rubén, Durán Inma, Molina-López Rafael A, Darwich Laila
Departament de Sanitat i Anatomia Animal, Universitat Autònoma de Barcelona, Barcelona, Spain.
Departamento Veterinaria de Laboratorios Echevarne, Barcelona, Spain.
Front Microbiol. 2021 Jan 20;11:621597. doi: 10.3389/fmicb.2020.621597. eCollection 2020.
Pet animals are assumed to be potential reservoirs in transferring antimicrobial resistance (AMR) to humans due to the extensively applied broad-spectrum antimicrobial agents and their close contact with humans. In this study, microbiological data and antimicrobial susceptibility results of dog ( = 5,086) and cat ( = 789) clinical samples from a private Laboratory of Diagnosis in Barcelona were analyzed. Samples came from different counties of the Iberian Peninsula during 2016-2018. In dogs, clinical samples were most commonly from otitis, and in cats from wounds, respiratory tract infections and conjunctivitis. In both pet groups, spp. (31% in dogs vs 30% in cats), spp. (19% vs 17%), spp. (16% vs 10%), (8% vs 5.6%), and spp. (5.5% vs 6.8%) were shown as the most predominant bacteria. However, higher frequencies of , , and were found in dogs, while and were more prevalent in cats. The antimicrobial susceptibility testing demonstrated that spp. and spp. presented the highest levels of AMR in both dogs and cats. Within the Enterobacteriaceae, showed low levels of AMR compared to , , or spp. Respiratory tract infections caused by presented higher AMR in cats. By contrast, isolates from the respiratory tract were highly sensitive to all the antimicrobials in cats and dogs. Data from this study could be used to guide empirical antimicrobial selection in companion animal veterinary practices in the Iberian Peninsula.
由于广泛使用广谱抗菌药物以及宠物与人类的密切接触，宠物被认为是将抗菌药物耐药性（AMR）传播给人类的潜在宿主。在本研究中，分析了来自巴塞罗那一家私人诊断实验室的5086份犬类和789份猫类临床样本的微生物学数据和抗菌药物敏感性结果。样本来自伊比利亚半岛不同郡县，时间跨度为2016年至2018年。犬类临床样本最常见于中耳炎，猫类临床样本则来自伤口、呼吸道感染和结膜炎。在这两个宠物群体中，葡萄球菌属（犬类中占31%，猫类中占30%）、链球菌属（19%对17%）、肠杆菌属（16%对10%）、大肠杆菌（8%对5.6%）和克雷伯菌属（5.5%对6.8%）被显示为最主要的细菌。然而，犬类中发现的不动杆菌属、变形杆菌属和摩根菌属的频率更高，而猫类中普罗威登斯菌属和沙雷菌属更为普遍。抗菌药物敏感性测试表明，葡萄球菌属和肠杆菌属在犬类和猫类中均呈现出最高水平的AMR。在肠杆菌科中，与肺炎克雷伯菌、阴沟肠杆菌或产气肠杆菌相比，大肠埃希菌的AMR水平较低。猫类中由肺炎克雷伯菌引起的呼吸道感染表现出更高的AMR。相比之下，呼吸道分离出的铜绿假单胞菌对犬类和猫类的所有抗菌药物均高度敏感。本研究的数据可用于指导伊比利亚半岛伴侣动物兽医实践中的经验性抗菌药物选择。
