南欧与自闭症谱系障碍相关的环境因素：一项系统综述。
Environmental factors associated with autism spectrum disorder in Southern Europe: a systematic review.
作者信息
Kazantzidou Panagiota, Antonopoulou Katerina, Costarelli Vasiliki, Papanikolaou George
机构信息
Department of Economics and Sustainable Development, Harokopio University, Athens, Greece.
Department of Dietetics and Nutritional Sciences, Harokopio University, Athens, Greece.
出版信息
Int J Dev Disabil. 2023 May 23;71(1):30-40. doi: 10.1080/20473869.2023.2215012. eCollection 2025.
The aetiology of autism spectrum disorder (ASD) is heterogeneous and is attributed to the concurrent interaction of a number of genetic and environmental factors. The steady increase in ASD rates in recent years makes the detection and study of environmental risk factors increasingly important. This systematic review identifies potential environmental factors associated with ASD focusing specifically on recent studies conducted in selected Southern European countries. Nine relevant studies were selected for this systematic review. Results indicate that ASD in Southern Europe is associated with a variety of prenatal, perinatal and postnatal environmental factors, including stressful early life events, maternal infection during pregnancy, delivery mode and perinatal complications or breastfeeding problems in the offspring. Specially designed, large population-based birth cohort studies are needed in Southern Europe, to allow precise assessment of potential environmental confounders and elucidate their association with ASD.
自闭症谱系障碍（ASD）的病因是异质性的，归因于多种遗传和环境因素的共同作用。近年来，ASD发病率稳步上升，使得环境危险因素的检测和研究变得越来越重要。本系统综述确定了与ASD相关的潜在环境因素，特别关注在选定的南欧国家进行的近期研究。本系统综述选取了九项相关研究。结果表明，南欧的ASD与多种产前、围产期和产后环境因素有关，包括早年生活应激事件、孕期母亲感染、分娩方式以及子代的围产期并发症或母乳喂养问题。南欧需要开展专门设计的、基于大规模人群的出生队列研究，以便精确评估潜在的环境混杂因素，并阐明它们与ASD的关联。
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